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- W2735137966 abstract "Antimicrobial resistance is one of the most significant health challenges worldwide. Meropenem is a broad spectrum beta-lactam antibiotic that possesses high activity against Gram-positive and Gram-negative bacteria. However, it has a short plasma half-life, and thus requiring frequent administration of high doses. For the first time, meropenem-loaded chitosan nanoparticles were prepared and evaluated as a potential tool to overcome antimicrobial resistance and to improve pharmacokinetics of the drug. Spherical nanosized particles were prepared and demonstrated ultrahigh encapsulation efficiency of meropenem (i.e. 76.3%). The nanoparticles could be stored in a freeze-dried powdered form while maintaining their physicochemical characteristics. In vitro, higher antibacterial activities of the drug-loaded nanoparticles were observed against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, as compared to the free drug. The nanoparticles were then tested in a septic rat model of Klebsiella pneumoniae and showed exceptional improvement of survival and bacterial clearance, as compared to the animals treated with the free drug. Hence, meropenem-loaded chitosan nanoparticles might have great potential for overcoming antimicrobial resistance." @default.
- W2735137966 created "2017-07-21" @default.
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- W2735137966 date "2017-10-01" @default.
- W2735137966 modified "2023-09-26" @default.
- W2735137966 title "Ultrahigh antibacterial efficacy of meropenem-loaded chitosan nanoparticles in a septic animal model" @default.
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- W2735137966 doi "https://doi.org/10.1016/j.carbpol.2017.07.030" @default.
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- W2735137966 hasPublicationYear "2017" @default.
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