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- W2735169075 abstract "There is increasing evidence that the aetiology of atopic disorders and auto-immune diseases is associated with intestinal dysbiosis. The intestinal microbiota may therefore be considered to harbour tremendous potentials as a diagnostic biomarker of disease, and as a monitor of disease activity. Microbial alterations seem to occur prior to disease onset, strengthening the hypothesis that gut microbiota may play an etiologic role in their development. Furthermore, the onset and the natural course of disease may be influenced by preventive therapeutic strategies manipulating the microbiota, such as dietary advice, prebiotics, probiotics and faecal transplantation. Despite promising results in experimental studies, mainly in animal models, manipulation of the intestinal microbiota in children with atopic disorders and auto-immune diseases is currently disappointing in terms of treatment outcome; it is hampered by insufficient insight in disease-specific microbial signatures. Furthermore, the patterns of microbial dysbiosis in affected study subjects are inconsistent, mainly due to differences in strategies regarding sample harvesting, collection and storage, and microbiota detection techniques. Expanding knowledge may provide opportunities to further explore the options to develop individualised preventive and therapeutic interventions in paediatric atopic and auto-immune diseases, including the use of prebiotics and probiotics and faecal transplantation. In this chapter, an overview is given of the available evidence on the role of intestinal microbiota in aetiology of auto-immune diseases and atopic disorders in childhood. In addition, potential benefits of preventive and therapeutic microbiota-based interventions are discussed." @default.
- W2735169075 created "2017-07-21" @default.
- W2735169075 creator A5050981112 @default.
- W2735169075 date "2017-07-28" @default.
- W2735169075 modified "2023-09-27" @default.
- W2735169075 title "Chapter 10 The intestinal microbiota and allergic and auto-immune disorders in children" @default.
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- W2735169075 doi "https://doi.org/10.3920/978-90-8686-839-1_10" @default.
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