FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735226312> ?p ?o ?g. }

• W2735226312 endingPage "2111" @default.
• W2735226312 startingPage "2104" @default.
• W2735226312 abstract "See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation increases amyloid-beta, suggesting that chronically disrupted sleep may promote amyloid plaques and other downstream Alzheimer's disease pathologies including tauopathy or inflammation. To date, studies have not examined which aspect of sleep modulates amyloid-beta or other Alzheimer's disease biomarkers. Seventeen healthy adults (age 35-65 years) without sleep disorders underwent 5-14 days of actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid collection the following morning for measurement of amyloid-beta, tau, total protein, YKL-40, and hypocretin. Data were compared to an identical protocol, with a sham condition during polysomnogram. Specific disruption of slow wave activity correlated with an increase in amyloid-beta40 (r = 0.610, P = 0.009). This effect was specific for slow wave activity, and not for sleep duration or efficiency. This effect was also specific to amyloid-beta, and not total protein, tau, YKL-40, or hypocretin. Additionally, worse home sleep quality, as measured by sleep efficiency by actigraphy in the six nights preceding lumbar punctures, was associated with higher tau (r = 0.543, P = 0.045). Slow wave activity disruption increases amyloid-beta levels acutely, and poorer sleep quality over several days increases tau. These effects are specific to neuronally-derived proteins, which suggests they are likely driven by changes in neuronal activity during disrupted sleep." @default.
• W2735226312 created "2017-07-21" @default.
• W2735226312 creator A5012964731 @default.
• W2735226312 creator A5025837253 @default.
• W2735226312 creator A5026408136 @default.
• W2735226312 creator A5027861338 @default.
• W2735226312 creator A5031918039 @default.
• W2735226312 creator A5036642361 @default.
• W2735226312 creator A5036751447 @default.
• W2735226312 creator A5058221297 @default.
• W2735226312 creator A5063691089 @default.
• W2735226312 creator A5066821454 @default.
• W2735226312 creator A5088998527 @default.
• W2735226312 date "2017-07-10" @default.
• W2735226312 modified "2023-10-17" @default.
• W2735226312 title "Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels" @default.
• W2735226312 cites W1538814448 @default.
• W2735226312 cites W1967884630 @default.
• W2735226312 cites W197066864 @default.
• W2735226312 cites W1973117088 @default.
• W2735226312 cites W1983875592 @default.
• W2735226312 cites W1992999217 @default.
• W2735226312 cites W2002716918 @default.
• W2735226312 cites W2003470703 @default.
• W2735226312 cites W2006858320 @default.
• W2735226312 cites W2013333500 @default.
• W2735226312 cites W2046952010 @default.
• W2735226312 cites W2065565096 @default.
• W2735226312 cites W2083765418 @default.
• W2735226312 cites W2109053359 @default.
• W2735226312 cites W2113732004 @default.
• W2735226312 cites W2114072206 @default.
• W2735226312 cites W2124443688 @default.
• W2735226312 cites W2136922708 @default.
• W2735226312 cites W2143790126 @default.
• W2735226312 cites W2151487996 @default.
• W2735226312 cites W2160311930 @default.
• W2735226312 cites W2163225965 @default.
• W2735226312 cites W2164765564 @default.
• W2735226312 cites W2166207589 @default.
• W2735226312 cites W2171259749 @default.
• W2735226312 cites W2262929199 @default.
• W2735226312 cites W2343799156 @default.
• W2735226312 cites W2518174992 @default.
• W2735226312 cites W2535921249 @default.
• W2735226312 cites W2589562338 @default.
• W2735226312 doi "https://doi.org/10.1093/brain/awx148" @default.
• W2735226312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790144" @default.
• W2735226312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28899014" @default.
• W2735226312 hasPublicationYear "2017" @default.
• W2735226312 type Work @default.
• W2735226312 sameAs 2735226312 @default.
• W2735226312 citedByCount "351" @default.
• W2735226312 countsByYear W27352263122017 @default.
• W2735226312 countsByYear W27352263122018 @default.
• W2735226312 countsByYear W27352263122019 @default.
• W2735226312 countsByYear W27352263122020 @default.
• W2735226312 countsByYear W27352263122021 @default.
• W2735226312 countsByYear W27352263122022 @default.
• W2735226312 countsByYear W27352263122023 @default.
• W2735226312 crossrefType "journal-article" @default.
• W2735226312 hasAuthorship W2735226312A5012964731 @default.
• W2735226312 hasAuthorship W2735226312A5025837253 @default.
• W2735226312 hasAuthorship W2735226312A5026408136 @default.
• W2735226312 hasAuthorship W2735226312A5027861338 @default.
• W2735226312 hasAuthorship W2735226312A5031918039 @default.
• W2735226312 hasAuthorship W2735226312A5036642361 @default.
• W2735226312 hasAuthorship W2735226312A5036751447 @default.
• W2735226312 hasAuthorship W2735226312A5058221297 @default.
• W2735226312 hasAuthorship W2735226312A5063691089 @default.
• W2735226312 hasAuthorship W2735226312A5066821454 @default.
• W2735226312 hasAuthorship W2735226312A5088998527 @default.
• W2735226312 hasBestOaLocation W27352263121 @default.
• W2735226312 hasConcept C101054994 @default.
• W2735226312 hasConcept C111919701 @default.
• W2735226312 hasConcept C142724271 @default.
• W2735226312 hasConcept C15744967 @default.
• W2735226312 hasConcept C169760540 @default.
• W2735226312 hasConcept C2775841894 @default.
• W2735226312 hasConcept C2777633098 @default.
• W2735226312 hasConcept C2779651940 @default.
• W2735226312 hasConcept C41008148 @default.
• W2735226312 hasConcept C71924100 @default.
• W2735226312 hasConceptScore W2735226312C101054994 @default.
• W2735226312 hasConceptScore W2735226312C111919701 @default.
• W2735226312 hasConceptScore W2735226312C142724271 @default.
• W2735226312 hasConceptScore W2735226312C15744967 @default.
• W2735226312 hasConceptScore W2735226312C169760540 @default.
• W2735226312 hasConceptScore W2735226312C2775841894 @default.
• W2735226312 hasConceptScore W2735226312C2777633098 @default.
• W2735226312 hasConceptScore W2735226312C2779651940 @default.
• W2735226312 hasConceptScore W2735226312C41008148 @default.
• W2735226312 hasConceptScore W2735226312C71924100 @default.
• W2735226312 hasFunder F4320332161 @default.
• W2735226312 hasIssue "8" @default.
• W2735226312 hasLocation W27352263121 @default.
• W2735226312 hasLocation W27352263122 @default.
• W2735226312 hasLocation W27352263123 @default.

• next