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- W2735251415 abstract "This current PhD Thesis (by published work / retrospective) in Neuroscience focuses on performedstudies of three crucial brain enzyme activities under seven categories of experimentally-simulated toxic and metabolic encephalopathies. The studied enzymes were: (a) acetylcholinesterase(AChE, EC 3.1.1.7), (b) sodium-potassium adenosine triphosphatase (Na+,K+-ATPase, EC 3.6.3.9, formerly EC 3.6.1.3), and (c) magnesium adenosine triphosphatase (Mg2+-ATPase, EC 3.6.3.2, formerly EC 3.6.1.3). The studied experimentally-simulated toxic andmetabolic encephalopathies were: (a) thyroid-hormone-related brain dysfunctions (as a resultof hyper- or hypothyroidism), (b) thioacetamide-induced fulminant hepatic encephalopathy,(c) streptozotocin-induced diabetic encephalopathy, (d) experimentally-simulated Wernicke’sencephalopathy (arising from chronic ethanol consumption, dietary thiaminedeprivationand pyrithiamine-administration), (e) manganese-induced neurotoxicity, (f) lanthanum-induced neurotoxicity, and (g) nickel-induced neurotoxicity. Enzymatic activitieswere determined spectrophotometrically on albino Wistar rat brain homogenates. Assessmentsof brain homogenates’ antioxidant status, in vivo antioxidant administrations, in vitroexperiments, brain homogenates’ enzymatic activity determinations, as well as pure enzymeactivity determinations (under various conditions), were performed (wherever required) inorder to elucidate the nature of some of the observed in vivo findings, to evaluate the potentiallimitations of the experimental-simulation techniques and / or to study the potential useof known antioxidants as neuroprotective agents. All experiments were performed at theMedical School of the National and Kapodistrian University of Athens. The current PhD Thesiscondenses and presents the significance of the aforementioned contribution to the study ofexperimentally-simulated toxic and metabolic encephalopathies, based on published work." @default.
- W2735251415 created "2017-07-21" @default.
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- W2735251415 date "2014-12-01" @default.
- W2735251415 modified "2023-09-27" @default.
- W2735251415 title "Contribution to the study of experimentally-simulated toxic and metabolic encephalopathies" @default.
- W2735251415 hasPublicationYear "2014" @default.
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