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- W2735275855 abstract "In Brief Improvement of long-term outcome of kidney transplantation has reached its limits due to consequences of efficient, but nonspecific immunosuppressive drugs. Mesenchymal stromal cells (MSC) have been proposed as an alternative strategy for more refined therapy. The interest in MSCs comes from their anti-inflammatory properties on the one hand and their propensity to ameliorate tissue damage and mediate repair on the other hand. First clinical trials have demonstrated that administration of MSCs in kidney transplant recipients is safe and feasible, and follow-up studies have been initiated with the desired clinical efficacy to reduce ischemia-reperfusion injury, to prevent/reverse acute transplant rejection, and to improve long-term transplant survival with minimization of immunosuppression. To further promote wider application of MSC in renal transplantation, it is of importance to determine efficacy, to increase the understanding of the mechanism of action, and to develop tools to identify eligible patients. In addition, we should overcome challenges particularly at the transition of early phase I studies to more advanced stages of clinical development. In this review, latest insights, first clinical experiences, and future challenges of MSC in solid organ transplantation are discussed. Mesenchymal stromal cell (MSC) activity is regulated by the inflammatory milieu and in turn they have immunoregulatory as well as tissue-repairing activities but important functional aspects are still unveiled. Clinical trials with MSC are ongoing on organ transplantation, GVHD and autoimmune diseases." @default.
- W2735275855 created "2017-07-21" @default.
- W2735275855 creator A5020130906 @default.
- W2735275855 creator A5035752811 @default.
- W2735275855 creator A5058384202 @default.
- W2735275855 creator A5069641539 @default.
- W2735275855 date "2018-01-01" @default.
- W2735275855 modified "2023-10-03" @default.
- W2735275855 title "Mesenchymal Stromal Cell Therapy for Solid Organ Transplantation" @default.
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