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• W2735367070 abstract "The aim of the study was to establish if the decrease in gait velocity on the 6 minute walk test relates to signs of neuromuscular junction dysfunction in spinal muscular atrophy type 3 patients. 6 minute walk test and low-rate repetitive nerve stimulation test were performed in fifteen ambulant patients with spinal muscular atrophy type 3 of age between 9 and 66 years. The 6 minute walk distance ranged between 66 and 575 m. The difference between the first and the 6th minute ranged between 0 and -69%. The low-rate repetitive nerve stimulation test measured in % of loss ranged between -31.7% to +4.2% to the axillary nerve. The correlation between 6 minute walk test changes and low-rate repetitive nerve stimulation test changes was 0.86. Our data suggest that the 6 minute walk test can identify fatigue in the ambulant type 3 patients who have a concurrent neuromuscular junction dysfunction. The identification of fatigue with a simple clinical test may help to target patients who may benefit from drugs that facilitate neuromuscular transmission." @default.
• W2735367070 created "2017-07-21" @default.
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• W2735367070 date "2017-10-01" @default.
• W2735367070 modified "2023-10-03" @default.
• W2735367070 title "6MWT can identify type 3 SMA patients with neuromuscular junction dysfunction" @default.
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• W2735367070 doi "https://doi.org/10.1016/j.nmd.2017.07.007" @default.
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