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- W2735376045 endingPage "94" @default.
- W2735376045 startingPage "69" @default.
- W2735376045 abstract "Zinc (Zn) is an essential element critical for numerous protein structures and catalytic functions. This chapter focuses on the importance of homeostatic concentrations and appropriate subcellular distributions of Zn within cells, as well as the structural and catalytic roles Zn plays for many important enzymes. The mechanisms and factors by which homeostatic levels of intracellular Zn are maintained are discussed, as well as means by which Zn is distributed within the cell. In addition, several important proteins that require Zn for catalytic activity, such as matrix metalloproteinases and lysine deacetylases, and structural functions, such as the transcription factor p53, are reviewed. Associations between the dysregulation of Zn-dependent proteins or intracellular Zn homeostasis and the development and progression of several cancers are detailed, with emphasis placed on mechanistic links related to Zn. Finally, the various chemotherapeutic strategies that have been developed to either modify intracellular Zn levels or directly target cancer-associated proteins that involve Zn and potential future chemotherapeutic targets are evaluated." @default.
- W2735376045 created "2017-07-21" @default.
- W2735376045 creator A5008639269 @default.
- W2735376045 creator A5075188715 @default.
- W2735376045 date "2017-01-01" @default.
- W2735376045 modified "2023-10-16" @default.
- W2735376045 title "Zinc and Zinc-Dependent Proteins in Cancer and Chemotherapeutics" @default.
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