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• W2735403896 abstract "Cellular respiration is a vital process for the existence of life. Any condition that results in deprivation of oxygen (also termed as hypoxia) may eventually lead to deleterious effects on the functioning of tissues. Brain being the highest consumer of oxygen is prone to increased risk of hypoxia-induced neurological insults. This in turn has been associated with many diseases of central nervous system (CNS) such as stroke, Alzheimer’s, encephalopathy etc. Although several studies have investigated the pathophysiological mechanisms underlying ischemic/hypoxic CNS diseases, the knowledge about protective therapeutic strategies to ameliorate the affected neuronal cells is meagre. This has augmented the need to improve our understanding of the hypoxic and ischemic events occurring in the brain and identify novel and alternate treatment modalities for such insults. MicroRNA (miRNAs), small non-coding RNA molecules, have recently emerged as potential neuroprotective agents as well as targets, under hypoxic conditions. These 18-22 nucleotide long RNA molecules are profusely present in brain and other organs and functions as gene regulators by cleaving and silencing the gene expression. In the brain, these are involved in synapse formation, neuronal differentiation, and plasticity. Therefore, targeting miRNA expression represents a novel therapeutic approach to intercede against hypoxic and ischemic brain injury. In the first part of this review, we will discuss the neurophysiological changes caused as a result of hypoxia, followed by the contribution of hypoxia in the neurodegenerative diseases. Secondly, we will provide recent updates and insights into the roles of miRNA in the regulation of genes in oxygen and glucose deprived brain in association with circadian rhythms and how these can be targeted as neuroprotective agents for CNS injuries. Finally, we will emphasize on alternate breathing or yogic interventions to overcome the hypoxia associated anomalies that could ultimately lead to improvement in cerebral perfusion." @default.
• W2735403896 created "2017-07-21" @default.
• W2735403896 creator A5009954546 @default.
• W2735403896 creator A5043066362 @default.
• W2735403896 creator A5046461979 @default.
• W2735403896 creator A5053968614 @default.
• W2735403896 creator A5069461062 @default.
• W2735403896 creator A5071556666 @default.
• W2735403896 date "2017-07-11" @default.
• W2735403896 modified "2023-09-28" @default.
• W2735403896 title "Hypoxia in CNS Pathologies: Emerging Role of miRNA-Based Neurotherapeutics and Yoga Based Alternative Therapies" @default.
• W2735403896 cites W144423133 @default.
• W2735403896 cites W1503667331 @default.
• W2735403896 cites W1537918536 @default.
• W2735403896 cites W1557444671 @default.
• W2735403896 cites W1579331768 @default.
• W2735403896 cites W1615911087 @default.
• W2735403896 cites W1777054565 @default.
• W2735403896 cites W1798615689 @default.
• W2735403896 cites W1963598207 @default.
• W2735403896 cites W1964401009 @default.
• W2735403896 cites W1964631913 @default.
• W2735403896 cites W1965345750 @default.
• W2735403896 cites W1965724936 @default.
• W2735403896 cites W1966054625 @default.
• W2735403896 cites W1966206179 @default.
• W2735403896 cites W1966577064 @default.
• W2735403896 cites W1967377184 @default.
• W2735403896 cites W1969614398 @default.
• W2735403896 cites W1970130718 @default.
• W2735403896 cites W1971234948 @default.
• W2735403896 cites W1972713603 @default.
• W2735403896 cites W1974425513 @default.
• W2735403896 cites W1975336035 @default.
• W2735403896 cites W1977381537 @default.
• W2735403896 cites W1977745306 @default.
• W2735403896 cites W1978105781 @default.
• W2735403896 cites W1979280463 @default.
• W2735403896 cites W1980269624 @default.
• W2735403896 cites W1981851389 @default.
• W2735403896 cites W1983199304 @default.
• W2735403896 cites W1984478703 @default.
• W2735403896 cites W1985584416 @default.
• W2735403896 cites W1988692970 @default.
• W2735403896 cites W1988863241 @default.
• W2735403896 cites W1989910375 @default.
• W2735403896 cites W1990066410 @default.
• W2735403896 cites W1992641327 @default.
• W2735403896 cites W1992731182 @default.
• W2735403896 cites W1993174988 @default.
• W2735403896 cites W1994246752 @default.
• W2735403896 cites W1996270959 @default.
• W2735403896 cites W1996527248 @default.
• W2735403896 cites W1999272982 @default.
• W2735403896 cites W1999399070 @default.
• W2735403896 cites W1999746960 @default.
• W2735403896 cites W2000278014 @default.
• W2735403896 cites W2001712818 @default.
• W2735403896 cites W2004125846 @default.
• W2735403896 cites W2004597645 @default.
• W2735403896 cites W2006092729 @default.
• W2735403896 cites W2006972722 @default.
• W2735403896 cites W2007726724 @default.
• W2735403896 cites W2012673817 @default.
• W2735403896 cites W2014474485 @default.
• W2735403896 cites W2014869583 @default.
• W2735403896 cites W2015489498 @default.
• W2735403896 cites W2015674248 @default.
• W2735403896 cites W2015727986 @default.
• W2735403896 cites W2017020667 @default.
• W2735403896 cites W2020189193 @default.
• W2735403896 cites W2020932061 @default.
• W2735403896 cites W2021654192 @default.
• W2735403896 cites W2024704386 @default.
• W2735403896 cites W2024716296 @default.
• W2735403896 cites W2024938223 @default.
• W2735403896 cites W2025452062 @default.
• W2735403896 cites W2025567420 @default.
• W2735403896 cites W2027099269 @default.
• W2735403896 cites W2028068115 @default.
• W2735403896 cites W2028924850 @default.
• W2735403896 cites W2028994878 @default.
• W2735403896 cites W2029031231 @default.
• W2735403896 cites W2029380028 @default.
• W2735403896 cites W2029754271 @default.
• W2735403896 cites W2030246737 @default.
• W2735403896 cites W2031406029 @default.
• W2735403896 cites W2032894309 @default.
• W2735403896 cites W2033486658 @default.
• W2735403896 cites W2033797433 @default.
• W2735403896 cites W2036534625 @default.
• W2735403896 cites W2036945415 @default.
• W2735403896 cites W2037835822 @default.
• W2735403896 cites W2038410213 @default.
• W2735403896 cites W2039075677 @default.
• W2735403896 cites W2039384122 @default.
• W2735403896 cites W2041387814 @default.
• W2735403896 cites W2042319725 @default.
• W2735403896 cites W2044586762 @default.
• W2735403896 cites W2048324184 @default.

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