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• W2735428857 abstract "A series of acyclic selenopurine nucleosides 3a-f and 4a-g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 µM) and HSV-2 (EC50 = 6.34 µM) activities without cytotoxicity up to 100 µM, while 2,6-diaminopurine derivatives 4e-g exhibited significant anti-human cytomegalovirus (HCMV) activity, which is slightly more potent than the guanine derivative 4d, indicating that they might act as prodrugs of seleno-ganciclovir (4d)." @default.
• W2735428857 created "2017-07-21" @default.
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• W2735428857 date "2017-07-12" @default.
• W2735428857 modified "2023-10-18" @default.
• W2735428857 title "Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents" @default.
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• W2735428857 doi "https://doi.org/10.3390/molecules22071167" @default.
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