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- W2735430942 abstract "The estrogen‐related receptor b (ESRRB) is an orphan nuclear receptor and targets many genes involved in self‐renewal and pluripotency. In mouse ES cells, overexpression of ESRRB can maintain LIF‐independent self‐renewal in the absence of Nanog. However, the fundamental features of porcine ESRRB remain elusive. In this study, we revealed the expression profiles of ESRRB in both porcine pluripotent stem cells and early stage embryos and dissected the functional domains of ESRRB protein to prove that ESRRB is a key transcription factor that enhanced porcine pluripotent gene activation. Addition of ESRRB into the cocktail of core pluripotent factors Oct4, Sox2, Klf4, and c‐Myc (OSKM + E) could significantly enhance the reprograming efficiency and the formation of alkaline phosphatase positive colonies. Conversely, knockdown of ESRRB in piPSCs significantly reduced the expression level of pluripotent genes, minimized the alkaline phosphatase activity, and initiated the porcine induced pluripotent stem cell differentiation. Therefore, porcine ESRRB is a crucial transcription factor to improve the self‐renewal of piPSCs." @default.
- W2735430942 created "2017-07-21" @default.
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- W2735430942 date "2017-07-31" @default.
- W2735430942 modified "2023-10-18" @default.
- W2735430942 title "ESRRB plays a crucial role in the promotion of porcine cell reprograming" @default.
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- W2735430942 doi "https://doi.org/10.1002/jcp.26063" @default.
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