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- W2735456019 endingPage "1419" @default.
- W2735456019 startingPage "1407" @default.
- W2735456019 abstract "Osteosarcoma is the most common primary bone malignancy in children and adolescents. Although improvements in therapeutic strategies were achieved, the outcome remains poor for most patients with metastatic or recurrent osteosarcoma. Therefore, it is imperative to identify novel and effective prognostic biomarker and therapeutic targets for the disease. Long noncoding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts >200 nucleotides that lack protein coding potential. Many lncRNAs are deregulated in cancer and are important regulators for malignancies. Nine lncRNAs (91H, BCAR4, FGFR3-AS1, HIF2PUT, HOTTIP, HULC, MALAT-1, TUG1, UCA1) are upregulated and considered oncogenic for osteosarcoma. Loc285194 and MEG3 are two lncRNAs downregulated and as tumor suppressor for the disease. Moreover, the expressions of LINC00161 and ODRUL are associated with chemo-resistance of osteosarcoma. The mechanisms for these lncRNAs in regulating development of osteosarcoma are diverse, e.g. ceRNA, Wnt/β-catenin pathway, etc. The lncRNAs identified may serve as potential biomarkers or therapeutic targets for osteosarcoma." @default.
- W2735456019 created "2017-07-21" @default.
- W2735456019 creator A5008144685 @default.
- W2735456019 creator A5026221168 @default.
- W2735456019 creator A5039958942 @default.
- W2735456019 creator A5081160539 @default.
- W2735456019 date "2017-01-01" @default.
- W2735456019 modified "2023-10-18" @default.
- W2735456019 title "Application of Long Noncoding RNAs in Osteosarcoma: Biomarkers and Therapeutic Targets" @default.
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