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- W2735469797 abstract "The new structural classes of ultrashort peptides that exhibit potent microbicidal action have potential as future drugs. Herein, we report that C-2 arylated histidines containing tripeptides His(2-Ar)-Trp-His(2-Ar) exhibit potent antifungal activity against Cryptococcus neoformans with high selectivity. The most potent peptide 12f [His(2-biphenyl)-Trp-His(2-biphenyl)] displayed high in vitro activity against C. neoformans (IC50 = 0.35 μg/mL, MIC = MFC = 0.63 μg/mL) with a selectivity index of >28 and 2 times higher potency compared to amphotericin B. Peptide 12f exhibited proteolytic stability, with no apparent hemolytic activity. The mechanism of action study of 12f by confocal laser scanning microscopy and electron microscopy indicates nuclear fragmentation and membrane disruption of C. neoformans cells. Combinations of 12f with fluconazole and amphotericin B at subinhibitory concentration were synergistic against C. neoformans. This study suggests that 12f is a new structural class of amphiphilic peptide with rapid fungicidal activity caused by C. neoformans." @default.
- W2735469797 created "2017-07-21" @default.
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- W2735469797 date "2017-07-25" @default.
- W2735469797 modified "2023-09-29" @default.
- W2735469797 title "Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of <i>Cryptococcus neoformans</i>" @default.
- W2735469797 cites W1531531679 @default.
- W2735469797 cites W1545518365 @default.
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- W2735469797 cites W1732388491 @default.
- W2735469797 cites W1860382351 @default.
- W2735469797 cites W1964937304 @default.
- W2735469797 cites W1965525585 @default.
- W2735469797 cites W1971926615 @default.
- W2735469797 cites W1976116943 @default.
- W2735469797 cites W1979749196 @default.
- W2735469797 cites W1983571177 @default.
- W2735469797 cites W1998801028 @default.
- W2735469797 cites W1998840608 @default.
- W2735469797 cites W2006832993 @default.
- W2735469797 cites W2009071690 @default.
- W2735469797 cites W2011035831 @default.
- W2735469797 cites W2011305963 @default.
- W2735469797 cites W2016562927 @default.
- W2735469797 cites W2027476525 @default.
- W2735469797 cites W2032122027 @default.
- W2735469797 cites W2032956001 @default.
- W2735469797 cites W2037893855 @default.
- W2735469797 cites W2038625884 @default.
- W2735469797 cites W2040438092 @default.
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- W2735469797 cites W2044882536 @default.
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- W2735469797 cites W2050798747 @default.
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- W2735469797 cites W2061492510 @default.
- W2735469797 cites W2061929532 @default.
- W2735469797 cites W2067234157 @default.
- W2735469797 cites W2068434462 @default.
- W2735469797 cites W2069898171 @default.
- W2735469797 cites W2070762622 @default.
- W2735469797 cites W2074995652 @default.
- W2735469797 cites W2075014095 @default.
- W2735469797 cites W2079665383 @default.
- W2735469797 cites W2084193558 @default.
- W2735469797 cites W2084315848 @default.
- W2735469797 cites W2087436516 @default.
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- W2735469797 cites W2097099115 @default.
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- W2735469797 cites W2131636532 @default.
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- W2735469797 cites W2137322869 @default.
- W2735469797 cites W2143224430 @default.
- W2735469797 cites W2146698584 @default.
- W2735469797 cites W2158445181 @default.
- W2735469797 cites W2160787060 @default.
- W2735469797 cites W2321441410 @default.
- W2735469797 cites W2331667782 @default.
- W2735469797 cites W2511688340 @default.
- W2735469797 cites W2517931900 @default.
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- W2735469797 doi "https://doi.org/10.1021/acs.jmedchem.7b00481" @default.
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- W2735469797 hasPublicationYear "2017" @default.
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