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- W2735528355 abstract "We described here an alternative method for the synthesis of 4-arylselanyl-7-chloroquinolines through reactions of 4,7-dichloroquinoline with organylselenols, generated in situ by the reaction of diorganyl diselenides with H3PO2 (50 wt% in H2O). These reactions proceeded efficiently at 60 °C under N2 atmosphere and are suitable to a range of diorganyl diselenides containing electron-donating and electron-withdrawing groups, affording the corresponding 4-aryl-7-chloroquinolines in high yields. The synthesized compounds were screened for their in vitro acetylcholinesterase (AChE) activity and our results demonstrated that the 7-chloro-4-[(4-fluorophenyl)selanyl]quinoline inhibited the AChE activity and improved memory in mice, making this compound is a potential therapeutic agent for the treatment of Alzheimer disease and other neurodegenerative disorders." @default.
- W2735528355 created "2017-07-21" @default.
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- W2735528355 date "2017-08-01" @default.
- W2735528355 modified "2023-10-16" @default.
- W2735528355 title "A simple method for the synthesis of 4-arylselanyl-7-chloroquinolines used as in vitro acetylcholinesterase inhibitors and in vivo memory improvement" @default.
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- W2735528355 doi "https://doi.org/10.1016/j.tetlet.2017.07.039" @default.
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