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- W2735547063 abstract "The ε2, ε3 and ε4 alleles of APOE gene have been associated with several diseases in different populations. Data on the frequency of alleles are used in both a clinical and evolutionary context. Although the data on frequency of these alleles are numerous, there are no reports for the population of Bosnia and Herzegovina.To estimate the frequency of APOE alleles in a healthy Bosnian population and compare it to data for other European populations.Overall, 170 unrelated Bosnian subjects (108 female and 62 male), aged 53.0 (±5.0) years were included in this study. Genotypes were determined by real-time PCR.In our group the prevalence of heterozygotes E2/E3, E2/E4 and E3/E4 was 20.6%, 3.5% and 12.9%, respectively, while the prevalence of homozygotes E2/E2, E3/E3, E4/E4 was 0.6%, 61.2% and 1.2%, respectively, with a mean frequency of ε2, ε3 and ε4 alleles of 12.6%, 78.0% and 9.4%, respectively.In studied European populations we observed a linear, gradually increasing trend in the frequency of ε4 allele from South to North (Pearson's test 0,7656, p value <0.00001), and the Bosnian population fits into this pattern perfectly." @default.
- W2735547063 created "2017-07-21" @default.
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- W2735547063 date "2017-07-13" @default.
- W2735547063 modified "2023-10-10" @default.
- W2735547063 title "Bosnian study of<i>APOE</i>distribution (BOSAD): a comparison with other European populations" @default.
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- W2735547063 doi "https://doi.org/10.1080/03014460.2017.1346708" @default.
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