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- W2735677419 abstract "Synuclein family consists of three members, α, β, and γ-synuclein. Due to their involvement in human diseases, they have been thoroughly investigated for the last 30 years. Since the first synuclein identification and description, members of this family are found in all vertebrates. Sequencing of their genes indicates high evolutionary conservation suggesting important function(s) of these proteins. They are small naturally unfolded proteins prone to aggregate, easily change their conformation, and bind to the membranes. The genes for α, β, and γ-synuclein have different chromosomal localization and a well preserved general organization composed of five coding exons of similar size. Three genes encoding synucleins are present in the majority of vertebrates, however, a variable number of synuclein genes are described in fishes of different species. An important question concerns their normal function in cells and tissues. α-Synuclein is implicated in the regulation of synaptic activity through regulation of synaptic vesicle release, while the physiological functions of two other members of the family is understood less clearly. Here we discuss recent results describing their role in the regulation of gene expression." @default.
- W2735677419 created "2017-07-21" @default.
- W2735677419 creator A5057934058 @default.
- W2735677419 creator A5074650983 @default.
- W2735677419 date "2017-07-13" @default.
- W2735677419 modified "2023-10-07" @default.
- W2735677419 title "Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?" @default.
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- W2735677419 doi "https://doi.org/10.3389/fnmol.2017.00224" @default.
- W2735677419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5508120" @default.