Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735697144> ?p ?o ?g. }
- W2735697144 endingPage "355" @default.
- W2735697144 startingPage "344" @default.
- W2735697144 abstract "Alzheimer’s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear. We show that spontaneous seizures increase expression of ΔFosB, a highly stable Fos-family transcription factor, in the hippocampus of an AD mouse model. ΔFosB suppressed expression of the immediate early gene c-Fos, which is critical for plasticity and cognition, by binding its promoter and triggering histone deacetylation. Acute histone deacetylase (HDAC) inhibition or inhibition of ΔFosB activity restored c-Fos induction and improved cognition in AD mice. Administration of seizure-inducing agents to nontransgenic mice also resulted in ΔFosB-mediated suppression of c-Fos, suggesting that this mechanism is not confined to AD mice. These results explain observations that c-Fos expression increases after acute neuronal activity but decreases with chronic activity. Moreover, these results indicate a general mechanism by which seizures contribute to persistent cognitive deficits, even during seizure-free periods." @default.
- W2735697144 created "2017-07-21" @default.
- W2735697144 creator A5008199212 @default.
- W2735697144 creator A5008695802 @default.
- W2735697144 creator A5008724389 @default.
- W2735697144 creator A5013402306 @default.
- W2735697144 creator A5019105102 @default.
- W2735697144 creator A5027168462 @default.
- W2735697144 creator A5045864908 @default.
- W2735697144 creator A5049993782 @default.
- W2735697144 creator A5054020195 @default.
- W2735697144 creator A5057667234 @default.
- W2735697144 creator A5058244346 @default.
- W2735697144 creator A5075583012 @default.
- W2735697144 creator A5084092720 @default.
- W2735697144 creator A5088203357 @default.
- W2735697144 creator A5089390826 @default.
- W2735697144 date "2017-07-01" @default.
- W2735697144 modified "2023-10-10" @default.
- W2735697144 title "ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer’s Disease" @default.
- W2735697144 cites W1511815964 @default.
- W2735697144 cites W1523349613 @default.
- W2735697144 cites W1555289101 @default.
- W2735697144 cites W1568472238 @default.
- W2735697144 cites W1584834830 @default.
- W2735697144 cites W1675950512 @default.
- W2735697144 cites W1770320011 @default.
- W2735697144 cites W1964597210 @default.
- W2735697144 cites W1967769642 @default.
- W2735697144 cites W1968937229 @default.
- W2735697144 cites W1970006557 @default.
- W2735697144 cites W1970910654 @default.
- W2735697144 cites W1982243354 @default.
- W2735697144 cites W1982373527 @default.
- W2735697144 cites W1985060509 @default.
- W2735697144 cites W1988590560 @default.
- W2735697144 cites W1990957877 @default.
- W2735697144 cites W1993915316 @default.
- W2735697144 cites W1995091281 @default.
- W2735697144 cites W2000696407 @default.
- W2735697144 cites W2001210466 @default.
- W2735697144 cites W2003320905 @default.
- W2735697144 cites W2004852048 @default.
- W2735697144 cites W2005290050 @default.
- W2735697144 cites W2020282265 @default.
- W2735697144 cites W2026802237 @default.
- W2735697144 cites W2027344089 @default.
- W2735697144 cites W2035527737 @default.
- W2735697144 cites W2035871717 @default.
- W2735697144 cites W2038120217 @default.
- W2735697144 cites W2045534779 @default.
- W2735697144 cites W2050552159 @default.
- W2735697144 cites W2050931169 @default.
- W2735697144 cites W2051075231 @default.
- W2735697144 cites W2053205229 @default.
- W2735697144 cites W2058754478 @default.
- W2735697144 cites W2060471640 @default.
- W2735697144 cites W2061272951 @default.
- W2735697144 cites W2062740397 @default.
- W2735697144 cites W2065432433 @default.
- W2735697144 cites W2068712780 @default.
- W2735697144 cites W2077464099 @default.
- W2735697144 cites W2082429191 @default.
- W2735697144 cites W2090054406 @default.
- W2735697144 cites W2092896141 @default.
- W2735697144 cites W2097084183 @default.
- W2735697144 cites W2098676436 @default.
- W2735697144 cites W2099778200 @default.
- W2735697144 cites W2103946141 @default.
- W2735697144 cites W2106900373 @default.
- W2735697144 cites W2109125430 @default.
- W2735697144 cites W2111786210 @default.
- W2735697144 cites W2115736681 @default.
- W2735697144 cites W2117918664 @default.
- W2735697144 cites W2124190705 @default.
- W2735697144 cites W2125644182 @default.
- W2735697144 cites W2129436612 @default.
- W2735697144 cites W2136190021 @default.
- W2735697144 cites W2149810560 @default.
- W2735697144 cites W2153768212 @default.
- W2735697144 cites W2161234653 @default.
- W2735697144 cites W2162129563 @default.
- W2735697144 cites W2163301650 @default.
- W2735697144 cites W2168312889 @default.
- W2735697144 cites W2168334242 @default.
- W2735697144 cites W2171590549 @default.
- W2735697144 cites W2308600021 @default.
- W2735697144 cites W2414380634 @default.
- W2735697144 cites W2527558243 @default.
- W2735697144 cites W4292291195 @default.
- W2735697144 cites W96512182 @default.
- W2735697144 doi "https://doi.org/10.1016/j.celrep.2017.06.040" @default.
- W2735697144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5785235" @default.
- W2735697144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28700937" @default.
- W2735697144 hasPublicationYear "2017" @default.
- W2735697144 type Work @default.
- W2735697144 sameAs 2735697144 @default.
- W2735697144 citedByCount "69" @default.