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• W2735717528 endingPage "59985" @default.
• W2735717528 startingPage "59977" @default.
• W2735717528 abstract "As an infrequent but potentially life-threatening hyperinflammatory syndrome, hemophagocytic lymphohistiocytosis (HLH) is clinically characterized with prolonged fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. Malignancy-associated HLH (M-HLH), one type of acquired HLH, usually presents variable overlaps of symptoms with other types of HLH, thus resulting in higher incidence of misdiagnosis and mortality. In recent years, with the increasing awareness to this disease, the diagnosis and management of HLH have gained more and more attention, and improvements have been made accordingly. As a result, the survival of patients is greatly prolonged. However, there is still no consensus on the diagnostic criteria and treatment strategies due to lack of large samples or prospective clinical trials. In order to improve recognition and diagnosis, and provide guidance regarding the treatment of M-HLH, the Study Group in HLH Subtypes of the Histiocyte Society has developed consensus recommendations for the diagnosis and management of M-HLH in 2015. In the present article, we summarized and discussed some updated understandings in M-HLH." @default.
• W2735717528 created "2017-07-21" @default.
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• W2735717528 date "2017-07-14" @default.
• W2735717528 modified "2023-10-18" @default.
• W2735717528 title "A systematic review of malignancy-associated hemophagocytic lymphohistiocytosis that needs more attentions" @default.
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• W2735717528 doi "https://doi.org/10.18632/oncotarget.19230" @default.
• W2735717528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5601794" @default.
• W2735717528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28938698" @default.
• W2735717528 hasPublicationYear "2017" @default.
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