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• W2735756413 startingPage "485" @default.
• W2735756413 abstract "Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders. Heterozygous Reeler Mice (HRM) and wildtype (WT) controls were treated with 50 mg/L of corticosterone (CORT) in their drinking water from 6 to 9 weeks of age, before undergoing behavioural testing in adulthood. We assessed methamphetamine-induced locomotor hyperactivity, prepulse inhibition (PPI) of acoustic startle, short-term spatial memory in the Y-maze, and depression-like behaviour in the Forced-Swim Test (FST). HRM genotype or CORT treatment did not affect methamphetamine-induced locomotor hyperactivity, a model of psychosis-like behaviour. At baseline, HRM showed decreased PPI at the commonly used 100 msec interstimulus interval (ISI), but not at the 30 msec ISI or following challenge with apomorphine. A history of CORT exposure potentiated immobility in the FST amongst HRM, but not WT mice. In the Y-maze, chronic CORT treatment decreased novel arm preference amongst HRM, reflecting reduced short-term spatial memory. These data confirm a significant role of endogenous reelin levels on stress-related behaviour, supporting a possible role in both bipolar disorder and schizophrenia. However, an interaction of reelin deficiency with dopaminergic regulation of psychosis-like behaviour remains unclear." @default.
• W2735756413 created "2017-07-21" @default.
• W2735756413 creator A5019635231 @default.
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• W2735756413 creator A5063883134 @default.
• W2735756413 date "2020-01-01" @default.
• W2735756413 modified "2023-10-18" @default.
• W2735756413 title "Interaction of reelin and stress on immobility in the forced swim test but not dopamine-mediated locomotor hyperactivity or prepulse inhibition disruption: Relevance to psychotic and mood disorders" @default.
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• W2735756413 doi "https://doi.org/10.1016/j.schres.2017.07.016" @default.
• W2735756413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28711473" @default.
• W2735756413 hasPublicationYear "2020" @default.
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