Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735757099> ?p ?o ?g. }
- W2735757099 abstract "Human papillomavirus (HPV) vaccines have been shown to be effective for the eradication of HPV and prevention of cervical cancer. However, the number of women who receive HPV vaccinations has decreased over the last several years in Japan, due to concerns about adverse reactions associated with the vaccines. We evaluated the safety of three types of HPV vaccines separately in young women and the difference in the risk of adverse reactions between HPV and other vaccines by conducting a meta-analysis. Primary literature was retrieved from MEDLINE, the Cochrane Central Register of Controlled Trials, and Japana Centra Revuo Medicina. Prospective controlled studies with participants consisting exclusively of healthy women who received bivalent, quadrivalent, or 9-valent HPV (2vHPV, 4vHPV or 9vHPV) vaccines were included. Primary safety outcome was the incidence of solicited local and systemic symptoms, and unsolicited symptoms. When two or more studies were found for the same analysis, a meta-analysis was applied. A total of 24 controlled studies from 22 articles were included in our study. Of the 24 studies, 16 were placebo-controlled and eight were active-controlled (different HPV vaccine or hepatitis vaccine). Average ages of the participants ranged from 12 to 37 years. A significantly higher incidence of solicited local symptoms was observed following injection of HPV vaccines (2vHPV and 4vHPV) compared to placebo, but there was no difference between HPV vaccines [risk ratio (RR) for 2vHPV: 1.25, 95% confidence interval (CI): 1.09 to 1.43, RR for 4vHPV: 1.16, 95% CI: 1.11 to 1.20]. The incidence of solicited systemic symptoms was not different between HPV vaccines and placebo (RR: 1.04, 95% CI: 0.99 to 1.09). The incidence of unsolicited symptoms was significantly higher for 2vHPV vaccine compared to placebo (RR: 1.28, 95% CI: 1.01 to 1.63), but was not significantly different between 2vHPV and hepatitis B vaccines. HPV vaccines had significantly higher risk of any injection site symptom compared to placebo or other vaccines (hepatitis A and B vaccines), and the incidence of solicited local symptoms was no difference between 2vHPV vaccination and 4vHPV vaccination. However, the most adverse reactions were transient." @default.
- W2735757099 created "2017-07-21" @default.
- W2735757099 creator A5015788149 @default.
- W2735757099 creator A5026549589 @default.
- W2735757099 creator A5032071441 @default.
- W2735757099 creator A5037605762 @default.
- W2735757099 date "2017-07-11" @default.
- W2735757099 modified "2023-10-16" @default.
- W2735757099 title "Safety of human papillomavirus vaccines in healthy young women: a meta-analysis of 24 controlled studies" @default.
- W2735757099 cites W1485697865 @default.
- W2735757099 cites W1520737453 @default.
- W2735757099 cites W1550722396 @default.
- W2735757099 cites W1582387697 @default.
- W2735757099 cites W1598602811 @default.
- W2735757099 cites W1808115300 @default.
- W2735757099 cites W1964375899 @default.
- W2735757099 cites W1966450723 @default.
- W2735757099 cites W1973196190 @default.
- W2735757099 cites W1978234305 @default.
- W2735757099 cites W1988984928 @default.
- W2735757099 cites W1995921537 @default.
- W2735757099 cites W2000659418 @default.
- W2735757099 cites W2020830322 @default.
- W2735757099 cites W2021144037 @default.
- W2735757099 cites W2027926090 @default.
- W2735757099 cites W2047368772 @default.
- W2735757099 cites W2047580791 @default.
- W2735757099 cites W2056922374 @default.
- W2735757099 cites W2085620777 @default.
- W2735757099 cites W2086323636 @default.
- W2735757099 cites W2087404749 @default.
- W2735757099 cites W2096729904 @default.
- W2735757099 cites W2096733107 @default.
- W2735757099 cites W2097683914 @default.
- W2735757099 cites W2099289950 @default.
- W2735757099 cites W2102327490 @default.
- W2735757099 cites W2104065542 @default.
- W2735757099 cites W2108446488 @default.
- W2735757099 cites W2112395947 @default.
- W2735757099 cites W2114391710 @default.
- W2735757099 cites W2117699409 @default.
- W2735757099 cites W2124248268 @default.
- W2735757099 cites W2125435699 @default.
- W2735757099 cites W2127043059 @default.
- W2735757099 cites W2128393824 @default.
- W2735757099 cites W2131597845 @default.
- W2735757099 cites W2135530875 @default.
- W2735757099 cites W2145150089 @default.
- W2735757099 cites W2145531750 @default.
- W2735757099 cites W2150436558 @default.
- W2735757099 cites W2155025175 @default.
- W2735757099 cites W2157196689 @default.
- W2735757099 cites W2159831861 @default.
- W2735757099 cites W2279505249 @default.
- W2735757099 cites W2519957152 @default.
- W2735757099 cites W2564668682 @default.
- W2735757099 cites W2566641645 @default.
- W2735757099 doi "https://doi.org/10.1186/s40780-017-0087-6" @default.
- W2735757099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5504559" @default.
- W2735757099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28702209" @default.
- W2735757099 hasPublicationYear "2017" @default.
- W2735757099 type Work @default.
- W2735757099 sameAs 2735757099 @default.
- W2735757099 citedByCount "11" @default.
- W2735757099 countsByYear W27357570992018 @default.
- W2735757099 countsByYear W27357570992019 @default.
- W2735757099 countsByYear W27357570992020 @default.
- W2735757099 countsByYear W27357570992021 @default.
- W2735757099 countsByYear W27357570992022 @default.
- W2735757099 crossrefType "journal-article" @default.
- W2735757099 hasAuthorship W2735757099A5015788149 @default.
- W2735757099 hasAuthorship W2735757099A5026549589 @default.
- W2735757099 hasAuthorship W2735757099A5032071441 @default.
- W2735757099 hasAuthorship W2735757099A5037605762 @default.
- W2735757099 hasBestOaLocation W27357570991 @default.
- W2735757099 hasConcept C120665830 @default.
- W2735757099 hasConcept C121332964 @default.
- W2735757099 hasConcept C121608353 @default.
- W2735757099 hasConcept C126322002 @default.
- W2735757099 hasConcept C142724271 @default.
- W2735757099 hasConcept C168563851 @default.
- W2735757099 hasConcept C197934379 @default.
- W2735757099 hasConcept C203014093 @default.
- W2735757099 hasConcept C204787440 @default.
- W2735757099 hasConcept C22070199 @default.
- W2735757099 hasConcept C27081682 @default.
- W2735757099 hasConcept C2778220009 @default.
- W2735757099 hasConcept C2778580637 @default.
- W2735757099 hasConcept C2780009117 @default.
- W2735757099 hasConcept C44249647 @default.
- W2735757099 hasConcept C61511704 @default.
- W2735757099 hasConcept C71924100 @default.
- W2735757099 hasConcept C82789193 @default.
- W2735757099 hasConcept C95190672 @default.
- W2735757099 hasConceptScore W2735757099C120665830 @default.
- W2735757099 hasConceptScore W2735757099C121332964 @default.
- W2735757099 hasConceptScore W2735757099C121608353 @default.
- W2735757099 hasConceptScore W2735757099C126322002 @default.
- W2735757099 hasConceptScore W2735757099C142724271 @default.
- W2735757099 hasConceptScore W2735757099C168563851 @default.