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- W2735820373 abstract "Blunt-ended DNase II-type breaks with 5' hydroxyls are generated in phagocytic cells of any lineage during digestion of the engulfed DNA. These breaks indicate the ongoing active phagocytic reaction. They are produced by the acid deoxyribonuclease-DNase II which is the primary endonuclease responsible for DNA degradation after its engulfment.Here, we present an express approach that detects blunt-ended 5' OH DNA breaks in fixed tissue sections. The technique is simple to perform and takes only 60 min to complete. It can be useful in studies of the clearance of dying cells in oncological, inflammatory, and autoimmune disorders." @default.
- W2735820373 created "2017-07-21" @default.
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- W2735820373 date "2017-01-01" @default.
- W2735820373 modified "2023-10-14" @default.
- W2735820373 title "Quick Detection of DNase II-Type Breaks in Formalin-Fixed Tissue Sections" @default.
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- W2735820373 doi "https://doi.org/10.1007/978-1-4939-7187-9_9" @default.
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