FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735833312> ?p ?o ?g. }

• W2735833312 abstract "Significance Optimal antigenic stimulation through T-cell receptors is required by T lymphocytes to exert full expansion, effector functions, and memory cell differentiation. Suboptimal TCR stimulation influences both transcription of genes and synthesis of subsets of proteins in a nonconcordant manner. Detailed polysome profiling revealed that weakly activated cells prioritized mRNA translation so that specific transcripts were translationally sequestered. Strikingly, ribosome biogenesis was compromised at both transcriptional and translational levels after weak stimulation, which still allowed the cells to undergo initial cell division, but proliferation was not sustained. Our work has demonstrated that T cells respond to environmental signals and use specific components of the translation machinery to regulate the translation of activation-dependent mRNAs." @default.
• W2735833312 created "2017-07-21" @default.
• W2735833312 creator A5025631895 @default.
• W2735833312 creator A5030046587 @default.
• W2735833312 creator A5032361534 @default.
• W2735833312 creator A5063056885 @default.
• W2735833312 creator A5079928079 @default.
• W2735833312 creator A5086704026 @default.
• W2735833312 date "2017-07-10" @default.
• W2735833312 modified "2023-10-16" @default.
• W2735833312 title "Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells" @default.
• W2735833312 cites W1711750427 @default.
• W2735833312 cites W1913368329 @default.
• W2735833312 cites W1964727443 @default.
• W2735833312 cites W1971692004 @default.
• W2735833312 cites W1974034863 @default.
• W2735833312 cites W1979819215 @default.
• W2735833312 cites W1980548655 @default.
• W2735833312 cites W1981117261 @default.
• W2735833312 cites W1986080935 @default.
• W2735833312 cites W1988018005 @default.
• W2735833312 cites W1991693470 @default.
• W2735833312 cites W1992456863 @default.
• W2735833312 cites W1998856404 @default.
• W2735833312 cites W2000656984 @default.
• W2735833312 cites W2001443196 @default.
• W2735833312 cites W2010869357 @default.
• W2735833312 cites W2013444425 @default.
• W2735833312 cites W2021764678 @default.
• W2735833312 cites W2023311524 @default.
• W2735833312 cites W2024276071 @default.
• W2735833312 cites W2024704480 @default.
• W2735833312 cites W2027453759 @default.
• W2735833312 cites W2029785503 @default.
• W2735833312 cites W2029797197 @default.
• W2735833312 cites W2035421116 @default.
• W2735833312 cites W2035562653 @default.
• W2735833312 cites W2043181600 @default.
• W2735833312 cites W2048565768 @default.
• W2735833312 cites W2052034618 @default.
• W2735833312 cites W2055018340 @default.
• W2735833312 cites W2055736811 @default.
• W2735833312 cites W2061074033 @default.
• W2735833312 cites W2068341455 @default.
• W2735833312 cites W2080531393 @default.
• W2735833312 cites W2090512296 @default.
• W2735833312 cites W2090895449 @default.
• W2735833312 cites W2091218020 @default.
• W2735833312 cites W2093902610 @default.
• W2735833312 cites W2094096693 @default.
• W2735833312 cites W2095907724 @default.
• W2735833312 cites W2096455435 @default.
• W2735833312 cites W2099814921 @default.
• W2735833312 cites W2099888531 @default.
• W2735833312 cites W2118953824 @default.
• W2735833312 cites W2127613576 @default.
• W2735833312 cites W2132199894 @default.
• W2735833312 cites W2133944986 @default.
• W2735833312 cites W2135792489 @default.
• W2735833312 cites W2135821923 @default.
• W2735833312 cites W2140899494 @default.
• W2735833312 cites W2143522905 @default.
• W2735833312 cites W2153032620 @default.
• W2735833312 cites W2164115182 @default.
• W2735833312 cites W2172163368 @default.
• W2735833312 cites W2191096966 @default.
• W2735833312 cites W2273444055 @default.
• W2735833312 cites W2300134937 @default.
• W2735833312 cites W4245666356 @default.
• W2735833312 doi "https://doi.org/10.1073/pnas.1700939114" @default.
• W2735833312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5544288" @default.
• W2735833312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28696283" @default.
• W2735833312 hasPublicationYear "2017" @default.
• W2735833312 type Work @default.
• W2735833312 sameAs 2735833312 @default.
• W2735833312 citedByCount "46" @default.
• W2735833312 countsByYear W27358333122018 @default.
• W2735833312 countsByYear W27358333122019 @default.
• W2735833312 countsByYear W27358333122020 @default.
• W2735833312 countsByYear W27358333122021 @default.
• W2735833312 countsByYear W27358333122022 @default.
• W2735833312 countsByYear W27358333122023 @default.
• W2735833312 crossrefType "journal-article" @default.
• W2735833312 hasAuthorship W2735833312A5025631895 @default.
• W2735833312 hasAuthorship W2735833312A5030046587 @default.
• W2735833312 hasAuthorship W2735833312A5032361534 @default.
• W2735833312 hasAuthorship W2735833312A5063056885 @default.
• W2735833312 hasAuthorship W2735833312A5079928079 @default.
• W2735833312 hasAuthorship W2735833312A5086704026 @default.
• W2735833312 hasBestOaLocation W27358333121 @default.
• W2735833312 hasConcept C104317684 @default.
• W2735833312 hasConcept C105580179 @default.
• W2735833312 hasConcept C131934819 @default.
• W2735833312 hasConcept C149364088 @default.
• W2735833312 hasConcept C153911025 @default.
• W2735833312 hasConcept C182325514 @default.
• W2735833312 hasConcept C19317047 @default.
• W2735833312 hasConcept C2776090121 @default.
• W2735833312 hasConcept C2779419633 @default.
• W2735833312 hasConcept C3675279 @default.

• next