Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735836734> ?p ?o ?g. }
- W2735836734 endingPage "29" @default.
- W2735836734 startingPage "21" @default.
- W2735836734 abstract "The integration of Process Analytical Technology (PAT) initiative into the continuous production of pharmaceuticals is indispensable for reliable production. The present paper reports the implementation of in-line Raman spectroscopy in a continuous blending and tableting process of a three-component model pharmaceutical system, containing caffeine as model active pharmaceutical ingredient (API), glucose as model excipient and magnesium stearate as lubricant. The real-time analysis of API content, blend homogeneity, and tablet content uniformity was performed using a Partial Least Squares (PLS) quantitative method. The in-line Raman spectroscopic monitoring showed that the continuous blender was capable of producing blends with high homogeneity, and technological malfunctions can be detected by the proposed PAT method. The Raman spectroscopy-based feedback control of the API feeder was also established, creating a 'Process Analytically Controlled Technology' (PACT), which guarantees the required API content in the produced blend. This is, to the best of the authors' knowledge, the first ever application of Raman-spectroscopy in continuous blending and the first Raman-based feedback control in the formulation technology of solid pharmaceuticals." @default.
- W2735836734 created "2017-07-21" @default.
- W2735836734 creator A5007010781 @default.
- W2735836734 creator A5025920759 @default.
- W2735836734 creator A5042634883 @default.
- W2735836734 creator A5047842613 @default.
- W2735836734 creator A5057009626 @default.
- W2735836734 creator A5064823224 @default.
- W2735836734 creator A5086496403 @default.
- W2735836734 creator A5088674084 @default.
- W2735836734 creator A5091353806 @default.
- W2735836734 date "2017-09-01" @default.
- W2735836734 modified "2023-10-12" @default.
- W2735836734 title "In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process" @default.
- W2735836734 cites W105695126 @default.
- W2735836734 cites W1786404767 @default.
- W2735836734 cites W1795156856 @default.
- W2735836734 cites W1968187681 @default.
- W2735836734 cites W1977625615 @default.
- W2735836734 cites W1987293746 @default.
- W2735836734 cites W2014325296 @default.
- W2735836734 cites W2016598362 @default.
- W2735836734 cites W2023969178 @default.
- W2735836734 cites W2026034321 @default.
- W2735836734 cites W2027409735 @default.
- W2735836734 cites W2043561929 @default.
- W2735836734 cites W2052981679 @default.
- W2735836734 cites W2053879423 @default.
- W2735836734 cites W2060838882 @default.
- W2735836734 cites W2066351615 @default.
- W2735836734 cites W2067251637 @default.
- W2735836734 cites W2075455679 @default.
- W2735836734 cites W2082458302 @default.
- W2735836734 cites W2083259132 @default.
- W2735836734 cites W2092699910 @default.
- W2735836734 cites W2099791969 @default.
- W2735836734 cites W2120212547 @default.
- W2735836734 cites W2177806555 @default.
- W2735836734 cites W2326412822 @default.
- W2735836734 cites W2328864716 @default.
- W2735836734 cites W2397698274 @default.
- W2735836734 cites W2399070630 @default.
- W2735836734 cites W2489376676 @default.
- W2735836734 cites W2497039129 @default.
- W2735836734 cites W2518691282 @default.
- W2735836734 cites W2587169644 @default.
- W2735836734 doi "https://doi.org/10.1016/j.ijpharm.2017.07.041" @default.
- W2735836734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28723408" @default.
- W2735836734 hasPublicationYear "2017" @default.
- W2735836734 type Work @default.
- W2735836734 sameAs 2735836734 @default.
- W2735836734 citedByCount "77" @default.
- W2735836734 countsByYear W27358367342018 @default.
- W2735836734 countsByYear W27358367342019 @default.
- W2735836734 countsByYear W27358367342020 @default.
- W2735836734 countsByYear W27358367342021 @default.
- W2735836734 countsByYear W27358367342022 @default.
- W2735836734 countsByYear W27358367342023 @default.
- W2735836734 crossrefType "journal-article" @default.
- W2735836734 hasAuthorship W2735836734A5007010781 @default.
- W2735836734 hasAuthorship W2735836734A5025920759 @default.
- W2735836734 hasAuthorship W2735836734A5042634883 @default.
- W2735836734 hasAuthorship W2735836734A5047842613 @default.
- W2735836734 hasAuthorship W2735836734A5057009626 @default.
- W2735836734 hasAuthorship W2735836734A5064823224 @default.
- W2735836734 hasAuthorship W2735836734A5086496403 @default.
- W2735836734 hasAuthorship W2735836734A5088674084 @default.
- W2735836734 hasAuthorship W2735836734A5091353806 @default.
- W2735836734 hasConcept C111919701 @default.
- W2735836734 hasConcept C119857082 @default.
- W2735836734 hasConcept C120665830 @default.
- W2735836734 hasConcept C121332964 @default.
- W2735836734 hasConcept C127413603 @default.
- W2735836734 hasConcept C142259097 @default.
- W2735836734 hasConcept C155386361 @default.
- W2735836734 hasConcept C159985019 @default.
- W2735836734 hasConcept C178144697 @default.
- W2735836734 hasConcept C185592680 @default.
- W2735836734 hasConcept C187530423 @default.
- W2735836734 hasConcept C192562407 @default.
- W2735836734 hasConcept C21880701 @default.
- W2735836734 hasConcept C2777239854 @default.
- W2735836734 hasConcept C2778572730 @default.
- W2735836734 hasConcept C2778938233 @default.
- W2735836734 hasConcept C2779849058 @default.
- W2735836734 hasConcept C2780449318 @default.
- W2735836734 hasConcept C40003534 @default.
- W2735836734 hasConcept C41008148 @default.
- W2735836734 hasConcept C42360764 @default.
- W2735836734 hasConcept C43617362 @default.
- W2735836734 hasConcept C45904493 @default.
- W2735836734 hasConcept C4916135 @default.
- W2735836734 hasConcept C60644358 @default.
- W2735836734 hasConcept C77281830 @default.
- W2735836734 hasConcept C86803240 @default.
- W2735836734 hasConcept C98045186 @default.
- W2735836734 hasConceptScore W2735836734C111919701 @default.
- W2735836734 hasConceptScore W2735836734C119857082 @default.