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• W2735848896 abstract "HSL inhibition is a promising approach to the treatment of dyslipidemia. As a result of re-optimization of lead compound 2, we identified novel compound 25a exhibiting potent inhibitory activity against HSL enzyme and cell with high selectivity for cholinesterases (AChE and BuChE). Reflecting its potent in vitro activity, compound 25a exhibited antilipolytic effect in rats at 1mg/kg p.o., which indicated that this novel compound is the most potent orally active HSL inhibitor. Moreover, compound 25a did not show bioactivation liability." @default.
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• W2735848896 date "2017-09-01" @default.
• W2735848896 modified "2023-09-26" @default.
• W2735848896 title "Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor" @default.
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• W2735848896 doi "https://doi.org/10.1016/j.bmc.2017.07.028" @default.
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