Matches in SemOpenAlex for { <https://semopenalex.org/work/W2735861671> ?p ?o ?g. }
- W2735861671 abstract "SUMMARY The past 17 years have been marked by a revolution in our understanding of cellular multisubunit DNA-dependent RNA polymerases (MSDDRPs) at the structural level. A parallel development over the past 15 years has been the emerging story of the giant viruses, which encode MSDDRPs. Here we link the two in an attempt to understand the specialization of multisubunit RNA polymerases in the domain of life encompassing the large nucleocytoplasmic DNA viruses (NCLDV), a superclade that includes the giant viruses and the biochemically well-characterized poxvirus vaccinia virus. The first half of this review surveys the recently determined structural biology of cellular RNA polymerases for a microbiology readership. The second half discusses a reannotation of MSDDRP subunits from NCLDV families and the apparent specialization of these enzymes by virus family and by subunit with regard to subunit or domain loss, subunit dissociability, endogenous control of polymerase arrest, and the elimination/customization of regulatory interactions that would confer higher-order cellular control. Some themes are apparent in linking subunit function to structure in the viral world: as with cellular RNA polymerases I and III and unlike cellular RNA polymerase II, the viral enzymes seem to opt for speed and processivity and seem to have eliminated domains associated with higher-order regulation. The adoption/loss of viral RNA polymerase proofreading functions may have played a part in matching intrinsic mutability to genome size." @default.
- W2735861671 created "2017-07-21" @default.
- W2735861671 creator A5044902025 @default.
- W2735861671 creator A5091545857 @default.
- W2735861671 date "2017-09-01" @default.
- W2735861671 modified "2023-10-09" @default.
- W2735861671 title "Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure" @default.
- W2735861671 cites W1492636245 @default.
- W2735861671 cites W1493342615 @default.
- W2735861671 cites W1498563943 @default.
- W2735861671 cites W1514790341 @default.
- W2735861671 cites W1529255301 @default.
- W2735861671 cites W1529969086 @default.
- W2735861671 cites W1534314296 @default.
- W2735861671 cites W1534326625 @default.
- W2735861671 cites W1574785618 @default.
- W2735861671 cites W1741551931 @default.
- W2735861671 cites W182034678 @default.
- W2735861671 cites W1911817655 @default.
- W2735861671 cites W1912050508 @default.
- W2735861671 cites W1920619128 @default.
- W2735861671 cites W1935374737 @default.
- W2735861671 cites W1967546327 @default.
- W2735861671 cites W1972091887 @default.
- W2735861671 cites W1972573548 @default.
- W2735861671 cites W1973488942 @default.
- W2735861671 cites W1974631225 @default.
- W2735861671 cites W1975140886 @default.
- W2735861671 cites W1975617736 @default.
- W2735861671 cites W198026508 @default.
- W2735861671 cites W1980719921 @default.
- W2735861671 cites W1981435058 @default.
- W2735861671 cites W1984583080 @default.
- W2735861671 cites W1989426516 @default.
- W2735861671 cites W1994330097 @default.
- W2735861671 cites W1994342611 @default.
- W2735861671 cites W1995198290 @default.
- W2735861671 cites W1996188270 @default.
- W2735861671 cites W2000317333 @default.
- W2735861671 cites W2000504635 @default.
- W2735861671 cites W2001155410 @default.
- W2735861671 cites W2001473029 @default.
- W2735861671 cites W2002428123 @default.
- W2735861671 cites W2002707838 @default.
- W2735861671 cites W2004546827 @default.
- W2735861671 cites W2004617021 @default.
- W2735861671 cites W2005561991 @default.
- W2735861671 cites W2005744558 @default.
- W2735861671 cites W2007093279 @default.
- W2735861671 cites W2008584102 @default.
- W2735861671 cites W2013059794 @default.
- W2735861671 cites W2013235095 @default.
- W2735861671 cites W2013364283 @default.
- W2735861671 cites W2013583348 @default.
- W2735861671 cites W2014612425 @default.
- W2735861671 cites W2018609064 @default.
- W2735861671 cites W2019422906 @default.
- W2735861671 cites W2020363034 @default.
- W2735861671 cites W2021608972 @default.
- W2735861671 cites W2023346112 @default.
- W2735861671 cites W2025043105 @default.
- W2735861671 cites W2025917903 @default.
- W2735861671 cites W2026574531 @default.
- W2735861671 cites W2030197516 @default.
- W2735861671 cites W2031742656 @default.
- W2735861671 cites W2033244846 @default.
- W2735861671 cites W2036166114 @default.
- W2735861671 cites W2038280179 @default.
- W2735861671 cites W2039659321 @default.
- W2735861671 cites W2042947978 @default.
- W2735861671 cites W2044001407 @default.
- W2735861671 cites W2044085514 @default.
- W2735861671 cites W2044690677 @default.
- W2735861671 cites W2051029106 @default.
- W2735861671 cites W2055989887 @default.
- W2735861671 cites W2056337863 @default.
- W2735861671 cites W2059691911 @default.
- W2735861671 cites W2060407367 @default.
- W2735861671 cites W2062246665 @default.
- W2735861671 cites W2063000913 @default.
- W2735861671 cites W2063291840 @default.
- W2735861671 cites W2063296736 @default.
- W2735861671 cites W2067953727 @default.
- W2735861671 cites W2072953422 @default.
- W2735861671 cites W2074206760 @default.
- W2735861671 cites W2074252380 @default.
- W2735861671 cites W2082286024 @default.
- W2735861671 cites W2083387716 @default.
- W2735861671 cites W2084622414 @default.
- W2735861671 cites W2088385058 @default.
- W2735861671 cites W2088815246 @default.
- W2735861671 cites W2090797443 @default.
- W2735861671 cites W2091187232 @default.
- W2735861671 cites W2091727198 @default.
- W2735861671 cites W2092558918 @default.
- W2735861671 cites W2093659250 @default.
- W2735861671 cites W2102782820 @default.
- W2735861671 cites W2103010558 @default.
- W2735861671 cites W2104057378 @default.
- W2735861671 cites W2104391251 @default.