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• W2735871558 abstract "<h3>Objective</h3> Y box-binding protein 1 (YB-1) is a potent oncogenic protein. How it regulates Snail in most tumors including cervical cancer is <i>unknown</i>. This article is to study if YB-1 plays a role in cervical cancer via regulating the expression of Snail. <h3>Methods</h3> Immunohistochemical staining of YB-1, Snail, and E-cadherin (E-cad) was performed <i>on tissue</i> specimens including 35 cases of chronic cervicitis (as a control), 35 cases of cervical intraepithelial neoplasm (CIN) I, 35 cases of CIN II/III, 28 cases of unmetastatic cervical squamous cell carcinoma, and 19 cases of metastatic cervical squamous cell carcinoma. <i>RNA interference technique was used to knock down YB-1, E6, and Snail genes.</i> Quantitative polymerase chain reaction, western blot, and transwell experiment were used to detect RNA, protein, and cell invasion of cervical cancer cell lines Hela and C33A, <i>respectively</i>. <h3>Results</h3> <i>First</i>, YB-1 knockdown significantly reduced messenger RNA (mRNA) and protein levels of Snail, followed by the increased mRNA and protein levels of E-cad <i>and the decreased invasive ability</i> in <i>both</i> Hela (human papillomavirus [HPV] 18+) and C33A (HPV−) cell lines. <i>Second</i>, YB-1 and Snail protein were correlatively expressed in the group order of metastatic cervical squamous cell carcinoma > unmetastatic cervical squamous cell carcinoma > CINs > cervicitis, with the inverse expression <i>mode</i> of E-cad in the group order, <i>P</i> value less than 0.01, between any 2 groups. Finally, HPV18 E6 knockdown reduced the mRNA and protein levels of YB-1 and Snail in Hela cells. <h3>Conclusions</h3> The results firstly reported that YB-1 <i>whose mRNA expression is regulated</i> by HPV18 E6 promotes epithelial-mesenchymal transition and progression of cervical cancer via enhancing the expressions of Snail, which indicated that YB-1/Snail/epithelial-mesenchymal transition axis could have a potential use in the diagnosis and therapy of cervical cancer metastasis as a cancer marker and molecular target." @default.
• W2735871558 created "2017-07-21" @default.
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• W2735871558 date "2017-10-01" @default.
• W2735871558 modified "2023-10-17" @default.
• W2735871558 title "Y Box-Binding Protein 1 Promotes Epithelial-Mesenchymal Transition, Invasion, and Metastasis of Cervical Cancer via Enhancing the Expressions of Snail" @default.
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• W2735871558 doi "https://doi.org/10.1097/igc.0000000000001066" @default.
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