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- W2735872183 abstract "The study was designed to evaluate the protective effect of α-mangostin and explore its mechanism in an in vitro model of Parkinson’s disease (PD) induced by rotenone. SH-SY5Y cells were treated with rotenone and α-mangostin for 24 h. α-Mangostin significantly and concentration-dependently inhibited rotenone-induced cytotoxicity. The rotenone-induced aggregation of α-synuclein and loss of TH were alleviated by α-mangostin. α-Mangostin treatment also reversed the rotenone-induced overproduction of reactive oxygen species, activation of caspases (−8 and −3) and mitochondrial dysfunction, reflected by decrease in mitochondrial membrane potential and cellular ATP levels. These findings suggest that α-mangostin has neuroprotective effects against PD-related neuronal injury." @default.
- W2735872183 created "2017-07-21" @default.
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- W2735872183 date "2017-07-11" @default.
- W2735872183 modified "2023-09-27" @default.
- W2735872183 title "Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson’s disease in differentiated SH-SY5Y cells" @default.
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- W2735872183 doi "https://doi.org/10.1080/10286020.2017.1339349" @default.
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