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• W2735897000 abstract "A (2+2+2) modular synthesis of multisubstituted quinazolines has been realized by the direct reaction of aryldiazonium salts with two equivalent of nitriles. Reaction of aryldiazonium salt with a nitrile provides the initial formation of a reactive nitrilium ion, which is attacked by another molecule of nitrile followed by electrophilic cyclization to deliver the desired product. Notable flexibility in the substitution patterns, readily available substrates, short reaction time, transition metal-free, and gram-scale synthesis are the advantages of this method." @default.
• W2735897000 created "2017-07-21" @default.
• W2735897000 creator A5043057413 @default.
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• W2735897000 date "2017-07-24" @default.
• W2735897000 modified "2023-09-26" @default.
• W2735897000 title "Preparation of Quinazolines via a 2+2+2 Annulation from Aryldiazonium Salts and Nitriles" @default.
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• W2735897000 doi "https://doi.org/10.1021/acs.joc.7b01325" @default.
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