Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736003860> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2736003860 endingPage "181" @default.
- W2736003860 startingPage "171" @default.
- W2736003860 abstract "Robustness of liquid chromatography-mass spectrometry (LC-MS) bioanalytical methods is critical in providing support for quantitative determination of drug candidates, metabolites, and endogenous biomarkers from biological matrices. This chapter discusses specificity enhancement in mass spectrometric detection in LC-MS bioanalysis. In particular, it focuses on differential mobility spectrometry (DMS) for reducing high chemical background noise, eliminating matrix interferences, and separating isobaric metabolites in quantitative LC-MS bioanalysis. Furthermore, the chapter illustrates strategies for enhancing the mass spectrometric specificity by utilizing high-resolution mass spectrometry (HRMS) in the LC-MS bioanalysis. These are two relatively new advances in quantitative bioanalysis that have been successfully used more extensively in target drug bioanalysis, and the trend increases to incorporate them in biomarker analysis. Besides DMS and HRMS, other traditional approaches of enhancing assay specificity such as column-switch technology, two-dimensional LC, derivatization, and orthogonal analysis such as comparing the data from LC-MS with ELISA may also be used when DMS or HRMS is unavailable." @default.
- W2736003860 created "2017-07-21" @default.
- W2736003860 creator A5004512587 @default.
- W2736003860 creator A5064231378 @default.
- W2736003860 date "2017-07-14" @default.
- W2736003860 modified "2023-10-17" @default.
- W2736003860 title "Strategies to Improve Specificity for Targeted Biomarker Quantitation by LC–MS" @default.
- W2736003860 cites W1968832728 @default.
- W2736003860 cites W1977839424 @default.
- W2736003860 cites W1983012121 @default.
- W2736003860 cites W1989812708 @default.
- W2736003860 cites W2014590342 @default.
- W2736003860 cites W2020833381 @default.
- W2736003860 cites W2025553450 @default.
- W2736003860 cites W2029607642 @default.
- W2736003860 cites W2037629853 @default.
- W2736003860 cites W2048897397 @default.
- W2736003860 cites W2073030344 @default.
- W2736003860 cites W2076189500 @default.
- W2736003860 cites W2084571497 @default.
- W2736003860 cites W2099769025 @default.
- W2736003860 cites W2111672836 @default.
- W2736003860 cites W2134586836 @default.
- W2736003860 cites W2141387425 @default.
- W2736003860 cites W2154157119 @default.
- W2736003860 cites W2291131594 @default.
- W2736003860 cites W2321700687 @default.
- W2736003860 cites W2427538250 @default.
- W2736003860 cites W2562801825 @default.
- W2736003860 doi "https://doi.org/10.1002/9781119413073.ch11" @default.
- W2736003860 hasPublicationYear "2017" @default.
- W2736003860 type Work @default.
- W2736003860 sameAs 2736003860 @default.
- W2736003860 citedByCount "1" @default.
- W2736003860 countsByYear W27360038602020 @default.
- W2736003860 crossrefType "other" @default.
- W2736003860 hasAuthorship W2736003860A5004512587 @default.
- W2736003860 hasAuthorship W2736003860A5064231378 @default.
- W2736003860 hasConcept C137535248 @default.
- W2736003860 hasConcept C162356407 @default.
- W2736003860 hasConcept C185592680 @default.
- W2736003860 hasConcept C2776923573 @default.
- W2736003860 hasConcept C43617362 @default.
- W2736003860 hasConcept C64489805 @default.
- W2736003860 hasConceptScore W2736003860C137535248 @default.
- W2736003860 hasConceptScore W2736003860C162356407 @default.
- W2736003860 hasConceptScore W2736003860C185592680 @default.
- W2736003860 hasConceptScore W2736003860C2776923573 @default.
- W2736003860 hasConceptScore W2736003860C43617362 @default.
- W2736003860 hasConceptScore W2736003860C64489805 @default.
- W2736003860 hasLocation W27360038601 @default.
- W2736003860 hasOpenAccess W2736003860 @default.
- W2736003860 hasPrimaryLocation W27360038601 @default.
- W2736003860 hasRelatedWork W2008473017 @default.
- W2736003860 hasRelatedWork W2058645934 @default.
- W2736003860 hasRelatedWork W2087241326 @default.
- W2736003860 hasRelatedWork W2095219531 @default.
- W2736003860 hasRelatedWork W2185025379 @default.
- W2736003860 hasRelatedWork W2798103833 @default.
- W2736003860 hasRelatedWork W2922172189 @default.
- W2736003860 hasRelatedWork W4256546821 @default.
- W2736003860 hasRelatedWork W4280604482 @default.
- W2736003860 hasRelatedWork W4323903764 @default.
- W2736003860 isParatext "false" @default.
- W2736003860 isRetracted "false" @default.
- W2736003860 magId "2736003860" @default.
- W2736003860 workType "other" @default.