Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736014558> ?p ?o ?g. }
- W2736014558 abstract "The Firmicutes are a phylum of bacteria that dominate numerous polymicrobial habitats of importance to human health and industry. Although these communities are often densely colonized, a broadly distributed contact-dependent mechanism of interbacterial antagonism utilized by Firmicutes has not been elucidated. Here we show that proteins belonging to the LXG polymorphic toxin family present in Streptococcus intermedius mediate cell contact- and Esx secretion pathway-dependent growth inhibition of diverse Firmicute species. The structure of one such toxin revealed a previously unobserved protein fold that we demonstrate directs the degradation of a uniquely bacterial molecule required for cell wall biosynthesis, lipid II. Consistent with our functional data linking LXG toxins to interbacterial interactions in S. intermedius, we show that LXG genes are prevalent in the human gut microbiome, a polymicrobial community dominated by Firmicutes. We speculate that interbacterial antagonism mediated by LXG toxins plays a critical role in shaping Firmicute-rich bacterial communities." @default.
- W2736014558 created "2017-07-21" @default.
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- W2736014558 date "2017-07-11" @default.
- W2736014558 modified "2023-10-03" @default.
- W2736014558 title "A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria" @default.
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- W2736014558 doi "https://doi.org/10.7554/elife.26938" @default.
- W2736014558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5555719" @default.
- W2736014558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28696203" @default.
- W2736014558 hasPublicationYear "2017" @default.
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