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• W2736136715 endingPage "1340" @default.
• W2736136715 startingPage "1327" @default.
• W2736136715 abstract "The objective of this test series was to elucidate the importance of selecting the right media composition for a biopredictive in-vitro dissolution screening of enteric-coated dosage forms.Drug release from immediate-release (IR) and enteric-coated (EC) aspirin formulations was assessed in phosphate-based and bicarbonate-based media with different pH, electrolyte composition and ionic strength.Drug release from aspirin IR tablets was unaffected by media composition. In contrast, drug release from EC aspirin formulations was affected by buffer species and ionic strength. In all media, drug release increased with increasing ionic strength, but in bicarbonate-based buffers was delayed when compared with that in phosphate-based buffers. Interestingly, the cation species in the dissolution medium had also a clear impact on drug release. Drug release profiles obtained in Blank CarbSIF, a new medium simulating pH and average ionic composition of small intestinal fluid, were different from those obtained in all other buffer compositions studied.Results from this study in which the impact of various media parameters on drug release of EC aspirin formulations was systematically screened clearly show that when developing predictive dissolution tests, it is important to simulate the ionic composition of intraluminal fluids as closely as possible." @default.
• W2736136715 created "2017-07-21" @default.
• W2736136715 creator A5037037002 @default.
• W2736136715 creator A5051152150 @default.
• W2736136715 date "2017-07-13" @default.
• W2736136715 modified "2023-10-10" @default.
• W2736136715 title "Assessing the influence of media composition and ionic strength on drug release from commercial immediate-release and enteric-coated aspirin tablets" @default.
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• W2736136715 doi "https://doi.org/10.1111/jphp.12777" @default.
• W2736136715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28703304" @default.
• W2736136715 hasPublicationYear "2017" @default.
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