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- W2736150726 abstract "This chapter reviews the theoretical background related to drug solubility and drug dissolution and introduces various techniques for determining solubility and dissolution with an emphasis on applications for the evaluation of drug substances and drug products. Solubility measurement of stable forms is relatively straightforward by using the shake flask method, whereas the study of metastable forms can be compromised by solution-mediated phase transformation. The solubility measurement usually involves equilibrating the drug and polymer for a certain period of time to allow dissolution of the crystalline drug into the amorphous polymer matrix. Dissolution testing developed according to pharmacopeial standards is carried out under a sink condition to ensure complete drug release. For nonsink dissolution, the amount of solid used is in excess of the amount required to reach the equilibrium solubility of the crystalline material, which can allow the amorphous material to maintain supersaturation over long time periods." @default.
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- W2736150726 date "2017-06-30" @default.
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- W2736150726 title "Solubility and Dissolution" @default.
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- W2736150726 doi "https://doi.org/10.1002/9781119264408.ch17" @default.
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