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• W2736171044 abstract "Abstract The prebiotic synthesis of canonical nucleobases from HCN is a cornerstone for the RNA world hypothesis. However, their role in the primordial pathways to RNA is still debated. The very same process starting from HCN also gives rise to orotic acid, which (via orotidine) plays a crucial role in extant biology in the de novo synthesis of uridine and cytidine, the informational base‐pairs in RNA. However, orotidine itself is absent in RNA. Given the prebiotic and biological relevance of orotic acid vis‐à‐vis uracil, we investigated orotidine‐containing RNA oligonucleotides and show that they have severely compromised base‐pairing properties. While not unexpected, these results suggest that the emergence of extant RNA cannot just be a consequence of the plausible prebiotic formation of its chemical constituents/building blocks. In combination with other investigations on alternative prebiotic nucleobases, sugars, and linkers, these findings imply that the selection of the components of extant RNA occurred at a higher hierarchical level of an oligomer/polymer based on its functional properties—pointing to a systems chemistry emergence of RNA from a library of precursors." @default.
• W2736171044 created "2017-07-21" @default.
• W2736171044 creator A5018319855 @default.
• W2736171044 creator A5044368710 @default.
• W2736171044 creator A5081322097 @default.
• W2736171044 date "2017-08-11" @default.
• W2736171044 modified "2023-10-17" @default.
• W2736171044 title "Orotidine‐Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA" @default.
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• W2736171044 doi "https://doi.org/10.1002/chem.201702912" @default.
• W2736171044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6311447" @default.
• W2736171044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28708927" @default.
• W2736171044 hasPublicationYear "2017" @default.
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