FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736173617> ?p ?o ?g. }

• W2736173617 abstract "Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role of this serine/threonine kinase in ameliorating lung inflammation. Other studies have shown sirolimus reduces/delays lung disease associated with various strains of influenza A virus (IAV). Thus, the effects of mTOR inhibitors on influenza infection deserve further studies. Here, we examined the changes in lung viral copies, pathology and pulmonary function associated with IAV (A/PR/8/34) infection in mice treated with sirolimus. Body weight loss peaked between days 6–11 post-infection and was more severe in IAV-infected mice that were administered sirolimus as compared to mice that received IAV alone (p = 0.030). Natural log viral gene copies, mean ± SD per mg lung tissue, in IAV-infected mice that were administered sirolimus were 17.31 ± 1.27 on day 4, 19.31 ± 7.46 on day 10, and 0 on day 25. The corresponding number of copies in mice that received IAV alone were 18.56 ± 0.95 on day 4 (p = 0.132), 1.52 ± 1.39 on day 10 (p = 0.008), and 0 on day 25. Lung pathology was evident on days 4, 10, and 25 post infection, with mean ± SD inflammatory score of 9.0 ± 4.5 in IAV-infected mice that were administered sirolimus, as compared to 11.5 ± 4.5 (p = 0.335) in mice received IAV alone (maximum score, 26.0). Impaired lung function was evident in IAV-infected mice on days 4 and 10, as demonstrated by increased airway resistance and decreased compliance. In this model, the effects of sirolimus on influenza infection included severe weight loss and modified viral replication, respiratory function and lung inflammation. The adverse events associated with sirolimus treatment are consistent with its potent immunosuppressive activity and, thus, preclude its use in IAV infection." @default.
• W2736173617 created "2017-07-21" @default.
• W2736173617 creator A5016680398 @default.
• W2736173617 creator A5021945180 @default.
• W2736173617 creator A5028539861 @default.
• W2736173617 creator A5037640842 @default.
• W2736173617 creator A5037980313 @default.
• W2736173617 creator A5063719583 @default.
• W2736173617 date "2017-07-11" @default.
• W2736173617 modified "2023-10-09" @default.
• W2736173617 title "Sirolimus alters lung pathology and viral load following influenza A virus infection" @default.
• W2736173617 cites W1589421810 @default.
• W2736173617 cites W1968092563 @default.
• W2736173617 cites W1979060462 @default.
• W2736173617 cites W1984134315 @default.
• W2736173617 cites W1990174512 @default.
• W2736173617 cites W1994143270 @default.
• W2736173617 cites W2006371316 @default.
• W2736173617 cites W2011507555 @default.
• W2736173617 cites W2023035638 @default.
• W2736173617 cites W2033764561 @default.
• W2736173617 cites W2067455566 @default.
• W2736173617 cites W2075982355 @default.
• W2736173617 cites W2097386432 @default.
• W2736173617 cites W2108724652 @default.
• W2736173617 cites W2113884542 @default.
• W2736173617 cites W2143112776 @default.
• W2736173617 cites W2161465846 @default.
• W2736173617 cites W2168238670 @default.
• W2736173617 cites W2333651123 @default.
• W2736173617 cites W2396080878 @default.
• W2736173617 cites W2403262325 @default.
• W2736173617 cites W2505945562 @default.
• W2736173617 cites W2515685060 @default.
• W2736173617 doi "https://doi.org/10.1186/s12931-017-0618-6" @default.
• W2736173617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5504865" @default.
• W2736173617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28693498" @default.
• W2736173617 hasPublicationYear "2017" @default.
• W2736173617 type Work @default.
• W2736173617 sameAs 2736173617 @default.
• W2736173617 citedByCount "27" @default.
• W2736173617 countsByYear W27361736172018 @default.
• W2736173617 countsByYear W27361736172019 @default.
• W2736173617 countsByYear W27361736172020 @default.
• W2736173617 countsByYear W27361736172021 @default.
• W2736173617 countsByYear W27361736172022 @default.
• W2736173617 countsByYear W27361736172023 @default.
• W2736173617 crossrefType "journal-article" @default.
• W2736173617 hasAuthorship W2736173617A5016680398 @default.
• W2736173617 hasAuthorship W2736173617A5021945180 @default.
• W2736173617 hasAuthorship W2736173617A5028539861 @default.
• W2736173617 hasAuthorship W2736173617A5037640842 @default.
• W2736173617 hasAuthorship W2736173617A5037980313 @default.
• W2736173617 hasAuthorship W2736173617A5063719583 @default.
• W2736173617 hasBestOaLocation W27361736171 @default.
• W2736173617 hasConcept C126322002 @default.
• W2736173617 hasConcept C142462285 @default.
• W2736173617 hasConcept C203014093 @default.
• W2736173617 hasConcept C2522874641 @default.
• W2736173617 hasConcept C2776914184 @default.
• W2736173617 hasConcept C2777546802 @default.
• W2736173617 hasConcept C2777714996 @default.
• W2736173617 hasConcept C2777921159 @default.
• W2736173617 hasConcept C71924100 @default.
• W2736173617 hasConcept C86803240 @default.
• W2736173617 hasConceptScore W2736173617C126322002 @default.
• W2736173617 hasConceptScore W2736173617C142462285 @default.
• W2736173617 hasConceptScore W2736173617C203014093 @default.
• W2736173617 hasConceptScore W2736173617C2522874641 @default.
• W2736173617 hasConceptScore W2736173617C2776914184 @default.
• W2736173617 hasConceptScore W2736173617C2777546802 @default.
• W2736173617 hasConceptScore W2736173617C2777714996 @default.
• W2736173617 hasConceptScore W2736173617C2777921159 @default.
• W2736173617 hasConceptScore W2736173617C71924100 @default.
• W2736173617 hasConceptScore W2736173617C86803240 @default.
• W2736173617 hasFunder F4320323593 @default.
• W2736173617 hasIssue "1" @default.
• W2736173617 hasLocation W27361736171 @default.
• W2736173617 hasLocation W27361736172 @default.
• W2736173617 hasLocation W27361736173 @default.
• W2736173617 hasLocation W27361736174 @default.
• W2736173617 hasLocation W27361736175 @default.
• W2736173617 hasOpenAccess W2736173617 @default.
• W2736173617 hasPrimaryLocation W27361736171 @default.
• W2736173617 hasRelatedWork W1987942028 @default.
• W2736173617 hasRelatedWork W2041396045 @default.
• W2736173617 hasRelatedWork W2115355689 @default.
• W2736173617 hasRelatedWork W2147028601 @default.
• W2736173617 hasRelatedWork W2168139530 @default.
• W2736173617 hasRelatedWork W2352778512 @default.
• W2736173617 hasRelatedWork W2919298355 @default.
• W2736173617 hasRelatedWork W2958551390 @default.
• W2736173617 hasRelatedWork W4248335412 @default.
• W2736173617 hasRelatedWork W93355781 @default.
• W2736173617 hasVolume "18" @default.
• W2736173617 isParatext "false" @default.
• W2736173617 isRetracted "false" @default.
• W2736173617 magId "2736173617" @default.
• W2736173617 workType "article" @default.