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• W2736242246 abstract "Abstract Chromatin looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromatin loops have been described. We have engineered a method for chromatin loop reorganization using CRISPR-dCas9 (CLOuD9) to selectively and reversibly establish chromatin loops. We demonstrate the power of this technology to selectively modulate gene expression at targeted loci." @default.
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• W2736242246 date "2017-07-13" @default.
• W2736242246 modified "2023-10-18" @default.
• W2736242246 title "Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping" @default.
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• W2736242246 doi "https://doi.org/10.1038/ncomms15993" @default.
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