Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736251380> ?p ?o ?g. }
- W2736251380 abstract "A cell’s epigenetic landscape governs its mitotically heritable patterns of gene expression and provides a basis for cell lineage specification during embryo development. The methylation of cytosine within DNA is one of the major epigenetic modifications of the genome. Changes to both global and base-specific patterns of DNA methylation are hallmarks of key developmental transitions in the embryo and are characteristic of each defined cell lineage. The epigenetic reprogramming to the pluripotent state is of particular relevance, as these cells have the capacity to differentiate into all of the cell types within the body. Genome-wide loss of DNA of methylation is a molecular hallmark of the formation of the two-pluripotent cell lineages within the embryo, the inner cell mass, and the primordial germ cells. Differentiation of these pluripotent cells requires cells to undergo patterns of remethylation that are specific to each new lineage formed. The profound epigenetic changes that occur during these embryonic transitions offer many opportunities for the introduction of errors in the formation of the epigenetic landscape. It is therefore not surprising that stress to gametes and embryos can perturb the normal epigenetic reprogramming and result in developmental and homeostatic instability with consequent increase in susceptibility to disease throughout life." @default.
- W2736251380 created "2017-07-21" @default.
- W2736251380 creator A5007366124 @default.
- W2736251380 date "2017-01-01" @default.
- W2736251380 modified "2023-09-27" @default.
- W2736251380 title "Dynamic Changes in DNA Modifications During Key Embryonic Transitions" @default.
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