Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736256689> ?p ?o ?g. }
- W2736256689 abstract "Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), one of the top 10 causes of death worldwide in 2015. The recent emergence of strains resistant to all current drugs urges the development of compounds with new mechanisms of action. G-quadruplexes are nucleic acids secondary structures that may form in G-rich regions to epigenetically regulate cellular functions. Here we implemented a computational tool to scan the presence of putative G-quadruplex forming sequences in the genome of Mycobacterium tuberculosis and analyse their association to transcription start sites. We found that the most stable G-quadruplexes were in the promoter region of genes belonging to definite functional categories. Actual G-quadruplex folding of four selected sequences was assessed by biophysical and biomolecular techniques: all molecules formed stable G-quadruplexes, which were further stabilized by two G-quadruplex ligands. These compounds inhibited Mycobacterium tuberculosis growth with minimal inhibitory concentrations in the low micromolar range. These data support formation of Mycobacterium tuberculosis G-quadruplexes in vivo and their potential regulation of gene transcription, and prompt the use of G4 ligands to develop original antitubercular agents." @default.
- W2736256689 created "2017-07-21" @default.
- W2736256689 creator A5010779114 @default.
- W2736256689 creator A5021297661 @default.
- W2736256689 creator A5024171817 @default.
- W2736256689 creator A5036561735 @default.
- W2736256689 creator A5069115725 @default.
- W2736256689 creator A5071924678 @default.
- W2736256689 creator A5089469128 @default.
- W2736256689 creator A5091348755 @default.
- W2736256689 date "2017-07-18" @default.
- W2736256689 modified "2023-10-16" @default.
- W2736256689 title "Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions" @default.
- W2736256689 cites W1862469243 @default.
- W2736256689 cites W1914649288 @default.
- W2736256689 cites W1985970608 @default.
- W2736256689 cites W1987006829 @default.
- W2736256689 cites W1988940164 @default.
- W2736256689 cites W1998940503 @default.
- W2736256689 cites W2005281689 @default.
- W2736256689 cites W2008090633 @default.
- W2736256689 cites W2015736211 @default.
- W2736256689 cites W2016386013 @default.
- W2736256689 cites W2021191052 @default.
- W2736256689 cites W2026370504 @default.
- W2736256689 cites W2028526843 @default.
- W2736256689 cites W2029468622 @default.
- W2736256689 cites W2039272200 @default.
- W2736256689 cites W2046332258 @default.
- W2736256689 cites W2050574321 @default.
- W2736256689 cites W2053439310 @default.
- W2736256689 cites W2054599183 @default.
- W2736256689 cites W2056201880 @default.
- W2736256689 cites W2059306569 @default.
- W2736256689 cites W2062169797 @default.
- W2736256689 cites W2072069024 @default.
- W2736256689 cites W2075316517 @default.
- W2736256689 cites W2076335297 @default.
- W2736256689 cites W2078929192 @default.
- W2736256689 cites W2082600364 @default.
- W2736256689 cites W2084038454 @default.
- W2736256689 cites W2090894089 @default.
- W2736256689 cites W2091300209 @default.
- W2736256689 cites W2105759091 @default.
- W2736256689 cites W2106154787 @default.
- W2736256689 cites W2107779830 @default.
- W2736256689 cites W2116128143 @default.
- W2736256689 cites W2119449687 @default.
- W2736256689 cites W2120574189 @default.
- W2736256689 cites W2121704353 @default.
- W2736256689 cites W2128345861 @default.
- W2736256689 cites W2130245511 @default.
- W2736256689 cites W2132096283 @default.
- W2736256689 cites W2134565464 @default.
- W2736256689 cites W2137500638 @default.
- W2736256689 cites W2138283130 @default.
- W2736256689 cites W2148660588 @default.
- W2736256689 cites W2150937967 @default.
- W2736256689 cites W2155347381 @default.
- W2736256689 cites W2155773930 @default.
- W2736256689 cites W2160884255 @default.
- W2736256689 cites W2165019352 @default.
- W2736256689 cites W2165400209 @default.
- W2736256689 cites W2167342214 @default.
- W2736256689 cites W2207694898 @default.
- W2736256689 cites W2239178919 @default.
- W2736256689 cites W2320172077 @default.
- W2736256689 cites W2327269273 @default.
- W2736256689 cites W2409818225 @default.
- W2736256689 cites W2419112435 @default.
- W2736256689 cites W2419736060 @default.
- W2736256689 cites W2514793060 @default.
- W2736256689 cites W2519514214 @default.
- W2736256689 cites W2521175609 @default.
- W2736256689 cites W2539691326 @default.
- W2736256689 cites W386594400 @default.
- W2736256689 cites W4246126472 @default.
- W2736256689 cites W943910173 @default.
- W2736256689 doi "https://doi.org/10.1038/s41598-017-05867-z" @default.
- W2736256689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5515968" @default.
- W2736256689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28720801" @default.
- W2736256689 hasPublicationYear "2017" @default.
- W2736256689 type Work @default.
- W2736256689 sameAs 2736256689 @default.
- W2736256689 citedByCount "64" @default.
- W2736256689 countsByYear W27362566892017 @default.
- W2736256689 countsByYear W27362566892018 @default.
- W2736256689 countsByYear W27362566892019 @default.
- W2736256689 countsByYear W27362566892020 @default.
- W2736256689 countsByYear W27362566892021 @default.
- W2736256689 countsByYear W27362566892022 @default.
- W2736256689 countsByYear W27362566892023 @default.
- W2736256689 crossrefType "journal-article" @default.
- W2736256689 hasAuthorship W2736256689A5010779114 @default.
- W2736256689 hasAuthorship W2736256689A5021297661 @default.
- W2736256689 hasAuthorship W2736256689A5024171817 @default.
- W2736256689 hasAuthorship W2736256689A5036561735 @default.
- W2736256689 hasAuthorship W2736256689A5069115725 @default.
- W2736256689 hasAuthorship W2736256689A5071924678 @default.
- W2736256689 hasAuthorship W2736256689A5089469128 @default.