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- W2736286144 abstract "Significance High-risk neuroblastoma remains a therapeutic challenge, and adjuvant retinoic acid (RA) treatment shows poor efficacy. We demonstrate that combined treatment with 5-Aza-deoxycytidine (AZA) and RA impedes neuroblastoma growth and induces a transcriptional response characterized by high levels of the HIF2α transcription factor. This approach targets high-risk neuroblastoma that responds poorly to RA. In addition, genome-wide analysis of treated tumors and patient data links HIF2α to tumor suppression, which is supported by a HIF2α-specific small molecule inhibitor-mediated block of the tumor response to AZA+RA treatment." @default.
- W2736286144 created "2017-07-21" @default.
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- W2736286144 date "2017-07-10" @default.
- W2736286144 modified "2023-10-14" @default.
- W2736286144 title "Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression" @default.
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- W2736286144 doi "https://doi.org/10.1073/pnas.1700655114" @default.
- W2736286144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5544284" @default.
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