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- W2736304895 abstract "A75 It is estimated that in 2007 there will be approximately 22,430 new cases and 15,280 deaths due to ovarian cancer in the US. This high fatality rate is due in part to late diagnosis of advanced-stage disease which has already spread beyond the ovary. A majority of ovarian tumors arise from the surface epithelium of the ovary. While cell signaling between ovarian surface epithelial cells and their supporting stromal cells is required to maintain normal function of the ovary, the signaling events between ovarian tumor epithelial cells and their surrounding stromal cells remain unclear. The aim of this study was to investigate alterations in gene expression that occur in tumor-derived versus normal stromal cells. We analyzed gene expression of 51 laser-capture microdissected tumor and 10 normal stromal samples by Affymetrix microarrays. BRB-ArrayTools software (NCI) was used to analyze the data. Unsupervised hierarchical clustering analysis clearly distinguished tumor-associated stroma from normal ovarian stroma. Supervised class comparison analysis identified 2,703 probe sets (p" @default.
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- W2736304895 date "2007-11-15" @default.
- W2736304895 modified "2023-09-25" @default.
- W2736304895 title "Gene expression profiling of microdissected stroma from normal and malignant ovary identifies a role for CTGF in ovarian tumor progression." @default.
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