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• W2736306093 startingPage "826" @default.
• W2736306093 abstract "Conventional drug delivery systems of docetaxel (DTX) are challenged with low drug loading efficiency and potential carriers-induced toxicity. In this work, a docetaxel prodrug self-assembled nanosystem was designed and synthesized by conjugating docetaxel with oleic acid (OA) exploring a thioether as the linker, which is redox-sensitive to the redox environment within tumor cells. Notably, the carrier-free nanomedicine which does not need any carrier has obviously high drug loading that reaches 58%. Moreover, the cytotoxicity of DTX-S-OA maintains an equal level with DTX. The novel prodrug conjugate therefore has a promising perspective as carrier-free nanomedicine for cancer therapy due to its high drug loading property, redox-sensitive release and long circulation mechanism." @default.
• W2736306093 created "2017-07-21" @default.
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• W2736306093 date "2018-02-01" @default.
• W2736306093 modified "2023-10-18" @default.
• W2736306093 title "Docetaxel prodrug self-assembled nanosystem: Synthesis, formulation and cytotoxicity" @default.
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• W2736306093 doi "https://doi.org/10.1016/j.bmcl.2017.07.041" @default.
• W2736306093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29395972" @default.
• W2736306093 hasPublicationYear "2018" @default.
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