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• W2736410947 abstract "<h3>BACKGROUND AND PURPOSE:</h3> The development of syringomyelia has been associated with changes in CSF flow dynamics in the spinal subarachnoid space. However, differences in CSF flow velocity between patients with posttraumatic syringomyelia and healthy participants remains unclear. The aim of this work was to define differences in CSF flow above and below a syrinx in participants with posttraumatic syringomyelia and compare the CSF flow with that in healthy controls. <h3>MATERIALS AND METHODS:</h3> Six participants with posttraumatic syringomyelia were recruited for this study. Phase-contrast MR imaging was used to measure CSF flow velocity at the base of the skull and above and below the syrinx. Velocity magnitudes and temporal features of the CSF velocity profile were compared with those in healthy controls. <h3>RESULTS:</h3> CSF flow velocity in the spinal subarachnoid space of participants with syringomyelia was similar at different locations despite differences in syrinx size and locations. Peak cranial and caudal velocities above and below the syrinx were not significantly different (peak cranial velocity, <i>P</i> = .9; peak caudal velocity, <i>P</i> = 1.0), but the peak velocities were significantly lower (<i>P</i> < .001, <i>P</i> = .007) in the participants with syringomyelia compared with matched controls. Most notably, the duration of caudal flow was significantly shorter (<i>P</i> = .003) in the participants with syringomyelia. <h3>CONCLUSIONS:</h3> CSF flow within the posttraumatic syringomyelia group was relatively uniform along the spinal canal, but there are differences in the timing of CSF flow compared with that in matched healthy controls. This finding supports the hypothesis that syrinx development may be associated with temporal changes in spinal CSF flow." @default.
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• W2736410947 date "2017-07-20" @default.
• W2736410947 modified "2023-10-12" @default.
• W2736410947 title "Characteristics of CSF Velocity-Time Profile in Posttraumatic Syringomyelia" @default.
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• W2736410947 doi "https://doi.org/10.3174/ajnr.a5304" @default.
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