FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736432480> ?p ?o ?g. }

• W2736432480 endingPage "980" @default.
• W2736432480 startingPage "970" @default.
• W2736432480 abstract "Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type–specific expression patterns and stability in peripheral blood. Objective: To identify circulating microRNAs associated with acute IS, determine their temporal course up to 90 days post-stroke, and explore their utility as an early diagnostic marker. Methods and Results: We used RNA sequencing to study expression changes of circulating microRNAs in a discovery sample of 20 patients with IS and 20 matched healthy control subjects. We further applied quantitative real-time polymerase chain reaction in independent samples for validation (40 patients with IS and 40 matched controls), replication (200 patients with IS, 100 healthy control subjects), and in 72 patients with transient ischemic attacks. Sampling of patient plasma was done immediately upon hospital arrival. We identified, validated, and replicated 3 differentially expressed microRNAs, which were upregulated in patients with IS compared with both healthy control subjects (miR-125a-5p [1.8-fold; P =1.5×10 −6 ], miR-125b-5p [2.5-fold; P =5.6×10 −6 ], and miR-143-3p [4.8-fold; P =7.8×10 −9 ]) and patients with transient ischemic attack (miR-125a-5p: P =0.003; miR-125b-5p: P =0.003; miR-143-3p: P =0.005). Longitudinal analysis of expression levels up to 90 days after stroke revealed a normalization to control levels for miR-125b-5p and miR-143-3p starting at day 2 while miR-125a-5p remained elevated. Levels of all 3 microRNAs depended on platelet numbers in a platelet spike-in experiment but were unaffected by chemical hypoxia in Neuro2a cells and in experimental stroke models. In a random forest classification, miR-125a-5p, miR-125b-5p, and miR-143-3p differentiated between healthy control subjects and patients with IS with an area under the curve of 0.90 (sensitivity: 85.6%; specificity: 76.3%), which was superior to multimodal cranial computed tomography obtained for routine diagnostics (sensitivity: 72.5%) and previously reported biomarkers of acute IS (neuron-specific enolase: area under the curve=0.69; interleukin 6: area under the curve=0.82). Conclusions: A set of circulating microRNAs (miR-125a-5p, miR-125b-5p, and miR-143-3p) associates with acute IS and might have clinical utility as an early diagnostic marker." @default.
• W2736432480 created "2017-07-31" @default.
• W2736432480 creator A5000710078 @default.
• W2736432480 creator A5005297652 @default.
• W2736432480 creator A5009747953 @default.
• W2736432480 creator A5022024157 @default.
• W2736432480 creator A5022072512 @default.
• W2736432480 creator A5024120001 @default.
• W2736432480 creator A5031597208 @default.
• W2736432480 creator A5031734036 @default.
• W2736432480 creator A5032736160 @default.
• W2736432480 creator A5061123357 @default.
• W2736432480 creator A5066625527 @default.
• W2736432480 creator A5071616613 @default.
• W2736432480 creator A5076920159 @default.
• W2736432480 creator A5081359784 @default.
• W2736432480 creator A5082939044 @default.
• W2736432480 creator A5086591547 @default.
• W2736432480 creator A5088588603 @default.
• W2736432480 date "2017-09-29" @default.
• W2736432480 modified "2023-10-10" @default.
• W2736432480 title "RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke" @default.
• W2736432480 cites W144423133 @default.
• W2736432480 cites W1896326023 @default.
• W2736432480 cites W1954145299 @default.
• W2736432480 cites W1964508430 @default.
• W2736432480 cites W1979853906 @default.
• W2736432480 cites W1980888291 @default.
• W2736432480 cites W1982810690 @default.
• W2736432480 cites W1987751736 @default.
• W2736432480 cites W1989029018 @default.
• W2736432480 cites W1996630410 @default.
• W2736432480 cites W1999272982 @default.
• W2736432480 cites W2003051202 @default.
• W2736432480 cites W2004173800 @default.
• W2736432480 cites W2015547750 @default.
• W2736432480 cites W2030516117 @default.
• W2736432480 cites W2032752697 @default.
• W2736432480 cites W2041184531 @default.
• W2736432480 cites W2053521005 @default.
• W2736432480 cites W2061371978 @default.
• W2736432480 cites W2072211192 @default.
• W2736432480 cites W2073560352 @default.
• W2736432480 cites W2077124851 @default.
• W2736432480 cites W2084419599 @default.
• W2736432480 cites W2090956762 @default.
• W2736432480 cites W2093478617 @default.
• W2736432480 cites W2094089023 @default.
• W2736432480 cites W2098170672 @default.
• W2736432480 cites W2101924691 @default.
• W2736432480 cites W2106418868 @default.
• W2736432480 cites W2112760185 @default.
• W2736432480 cites W2114104545 @default.
• W2736432480 cites W2115093090 @default.
• W2736432480 cites W2117391623 @default.
• W2736432480 cites W2118483175 @default.
• W2736432480 cites W2119782911 @default.
• W2736432480 cites W2120907478 @default.
• W2736432480 cites W2134088303 @default.
• W2736432480 cites W2138595885 @default.
• W2736432480 cites W2148511255 @default.
• W2736432480 cites W2148612363 @default.
• W2736432480 cites W2151968079 @default.
• W2736432480 cites W2157454492 @default.
• W2736432480 cites W2159627472 @default.
• W2736432480 cites W2170740525 @default.
• W2736432480 cites W2171165037 @default.
• W2736432480 cites W2179438025 @default.
• W2736432480 cites W2193219814 @default.
• W2736432480 cites W2260902767 @default.
• W2736432480 cites W2568954699 @default.
• W2736432480 cites W2614986146 @default.
• W2736432480 doi "https://doi.org/10.1161/circresaha.117.311572" @default.
• W2736432480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28724745" @default.
• W2736432480 hasPublicationYear "2017" @default.
• W2736432480 type Work @default.
• W2736432480 sameAs 2736432480 @default.
• W2736432480 citedByCount "181" @default.
• W2736432480 countsByYear W27364324802017 @default.
• W2736432480 countsByYear W27364324802018 @default.
• W2736432480 countsByYear W27364324802019 @default.
• W2736432480 countsByYear W27364324802020 @default.
• W2736432480 countsByYear W27364324802021 @default.
• W2736432480 countsByYear W27364324802022 @default.
• W2736432480 countsByYear W27364324802023 @default.
• W2736432480 crossrefType "journal-article" @default.
• W2736432480 hasAuthorship W2736432480A5000710078 @default.
• W2736432480 hasAuthorship W2736432480A5005297652 @default.
• W2736432480 hasAuthorship W2736432480A5009747953 @default.
• W2736432480 hasAuthorship W2736432480A5022024157 @default.
• W2736432480 hasAuthorship W2736432480A5022072512 @default.
• W2736432480 hasAuthorship W2736432480A5024120001 @default.
• W2736432480 hasAuthorship W2736432480A5031597208 @default.
• W2736432480 hasAuthorship W2736432480A5031734036 @default.
• W2736432480 hasAuthorship W2736432480A5032736160 @default.
• W2736432480 hasAuthorship W2736432480A5061123357 @default.
• W2736432480 hasAuthorship W2736432480A5066625527 @default.
• W2736432480 hasAuthorship W2736432480A5071616613 @default.

• next