Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736597120> ?p ?o ?g. }
- W2736597120 endingPage "2175" @default.
- W2736597120 startingPage "2175" @default.
- W2736597120 abstract "The lining of the gastrointestinal tract needs to be easily accessible to nutrients and, at the same time, defend against pathogens and chemical challenges. This lining is the largest and most vulnerable surface that faces the outside world. To manage the dual problems of effective nutrient conversion and defence, the gut lining has a sophisticated system for detection of individual chemical entities, pathogenic organisms and their products, and physico-chemical properties of its contents. Detection is through specific receptors that signal to the gut endocrine system, the nervous system, the immune system and local tissue defence systems. These effectors, in turn, modify digestive functions and contribute to tissue defence. Receptors for nutrients include taste receptors for sweet, bitter and savoury, free fatty acid receptors, peptide and phytochemical receptors, that are primarily located on enteroendocrine cells. Hormones released by enteroendocrine cells act locally, through the circulation and via the nervous system, to optimise digestion and mucosal health. Pathogen detection is both through antigen presentation to T-cells and through pattern-recognition receptors (PRRs). Activation of PRRs triggers local tissue defence, for example, by causing release of antimicrobials from Paneth cells. Toxic chemicals, including plant toxins, are sensed and then avoided, expelled or metabolised. It continues to be a major challenge to develop a comprehensive understanding of the integrated responses of the gastrointestinal tract to its luminal contents." @default.
- W2736597120 created "2017-07-31" @default.
- W2736597120 creator A5021448091 @default.
- W2736597120 creator A5091243598 @default.
- W2736597120 date "2017-01-01" @default.
- W2736597120 modified "2023-10-18" @default.
- W2736597120 title "Signalling from the gut lumen" @default.
- W2736597120 cites W1464228212 @default.
- W2736597120 cites W1486750235 @default.
- W2736597120 cites W1503073093 @default.
- W2736597120 cites W1503989407 @default.
- W2736597120 cites W1547288529 @default.
- W2736597120 cites W1576727246 @default.
- W2736597120 cites W1614693610 @default.
- W2736597120 cites W1940354221 @default.
- W2736597120 cites W1963843984 @default.
- W2736597120 cites W1964427017 @default.
- W2736597120 cites W1965193260 @default.
- W2736597120 cites W1969035712 @default.
- W2736597120 cites W1972267253 @default.
- W2736597120 cites W1974301183 @default.
- W2736597120 cites W1976348994 @default.
- W2736597120 cites W1977702120 @default.
- W2736597120 cites W1979748482 @default.
- W2736597120 cites W1980914602 @default.
- W2736597120 cites W1981157632 @default.
- W2736597120 cites W1982279452 @default.
- W2736597120 cites W1982955132 @default.
- W2736597120 cites W1985464800 @default.
- W2736597120 cites W1985672713 @default.
- W2736597120 cites W1987064421 @default.
- W2736597120 cites W1987836935 @default.
- W2736597120 cites W1989448739 @default.
- W2736597120 cites W1990236675 @default.
- W2736597120 cites W1990784939 @default.
- W2736597120 cites W1992503641 @default.
- W2736597120 cites W1995744610 @default.
- W2736597120 cites W1997608252 @default.
- W2736597120 cites W1999172670 @default.
- W2736597120 cites W1999528250 @default.
- W2736597120 cites W2003572328 @default.
- W2736597120 cites W2004454578 @default.
- W2736597120 cites W2010218922 @default.
- W2736597120 cites W2012074781 @default.
- W2736597120 cites W2012325805 @default.
- W2736597120 cites W2016614268 @default.
- W2736597120 cites W2016697142 @default.
- W2736597120 cites W2022689346 @default.
- W2736597120 cites W2024333046 @default.
- W2736597120 cites W2025114863 @default.
- W2736597120 cites W2026078091 @default.
- W2736597120 cites W2028418794 @default.
- W2736597120 cites W2030322836 @default.
- W2736597120 cites W2030817385 @default.
- W2736597120 cites W2031415677 @default.
- W2736597120 cites W2033253360 @default.
- W2736597120 cites W2035236261 @default.
- W2736597120 cites W2037927350 @default.
- W2736597120 cites W2041439233 @default.
- W2736597120 cites W2044560758 @default.
- W2736597120 cites W2044974031 @default.
- W2736597120 cites W2045081472 @default.
- W2736597120 cites W2045160890 @default.
- W2736597120 cites W2045323481 @default.
- W2736597120 cites W2046005140 @default.
- W2736597120 cites W2048278103 @default.
- W2736597120 cites W2051692635 @default.
- W2736597120 cites W2051753034 @default.
- W2736597120 cites W2056389649 @default.
- W2736597120 cites W2058889082 @default.
- W2736597120 cites W2061493853 @default.
- W2736597120 cites W2062423798 @default.
- W2736597120 cites W2063053656 @default.
- W2736597120 cites W2068445454 @default.
- W2736597120 cites W2069835983 @default.
- W2736597120 cites W2070134234 @default.
- W2736597120 cites W2070463722 @default.
- W2736597120 cites W2072417345 @default.
- W2736597120 cites W2077936393 @default.
- W2736597120 cites W2083787933 @default.
- W2736597120 cites W2090903806 @default.
- W2736597120 cites W2091077289 @default.
- W2736597120 cites W2099534015 @default.
- W2736597120 cites W2104777114 @default.
- W2736597120 cites W2104890139 @default.
- W2736597120 cites W2106089163 @default.
- W2736597120 cites W2107044225 @default.
- W2736597120 cites W2109762839 @default.
- W2736597120 cites W2114932688 @default.
- W2736597120 cites W2122332643 @default.
- W2736597120 cites W2127834830 @default.
- W2736597120 cites W2131609239 @default.
- W2736597120 cites W2131790950 @default.
- W2736597120 cites W2135356931 @default.
- W2736597120 cites W2138174591 @default.
- W2736597120 cites W2142106721 @default.
- W2736597120 cites W2143245895 @default.
- W2736597120 cites W2143952462 @default.