FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736633767> ?p ?o ?g. }

• W2736633767 endingPage "e0181473" @default.
• W2736633767 startingPage "e0181473" @default.
• W2736633767 abstract "Background Absorbed doses for α-emitters are different from those for β-emitters, as the high linear energy transfer (LET) nature of α-particles results in a very dense energy deposition over a relatively short path length near the point of emission. This highly localized and therefore high energy deposition can lead to enhanced cell-killing effects at absorbed doses that are non-lethal in low-LET type of exposure. Affinities of DOTA-DPhe1-Tyr3-octreotate (DOTATATE), 115In-DOTATATE, 175Lu-DOTATATE and 209Bi-DOTATATE were determined in the K562-SST2 cell line. Two other cell lines were used for radiation response assessment; BON and CA20948, with a low and high expression of somatostatin receptors, respectively. Cellular uptake kinetics of 111In-DOTATATE were determined in CA20948 cells. CA20948 and BON were irradiated with 137Cs, 177Lu-DTPA, 177Lu-DOTATATE, 213Bi-DTPA and 213Bi-DOTATATE. Absorbed doses were calculated using the MIRDcell dosimetry method for the specific binding and a Monte Carlo model of a cylindrical 6-well plate geometry for the exposure by the radioactive incubation medium. Absorbed doses were compared to conventional irradiation of cells with 137Cs and the relative biological effect (RBE) at 10% survival was calculated. Results IC50 of (labelled) DOTATATE was in the nM range. Absorbed doses up to 7 Gy were obtained by 5.2 MBq 213Bi-DOTATATE, in majority the dose was caused by α-particle radiation. Cellular internalization determined with 111In-DOTATATE showed a linear relation with incubation time. Cell survival after exposure of 213Bi-DTPA and 213Bi-DOTATATE to BON or CA20948 cells showed a linear-exponential relation with the absorbed dose, confirming the high LET character of 213Bi. The survival of CA20948 after exposure to 177Lu-DOTATATE and the reference 137Cs irradiation showed the typical curvature of the linear-quadratic model. 10% Cell survival of CA20948 was reached at 3 Gy with 213Bi-DOTATATE, a factor 6 lower than the 18 Gy found for 177Lu-DOTATATE and also below the 5 Gy after 137Cs external exposure. Conclusion 213Bi-DTPA and 213Bi-DOTATATE lead to a factor 6 advantage in cell killing compared to 177Lu-DOTATATE. The RBE at 10% survival by 213Bi-ligand compared to 137Cs was 2.0 whereas the RBE for 177Lu-DOTATATE was 0.3 in the CA20948 in vitro model." @default.
• W2736633767 created "2017-07-31" @default.
• W2736633767 creator A5000332171 @default.
• W2736633767 creator A5007539874 @default.
• W2736633767 creator A5011219611 @default.
• W2736633767 creator A5040369608 @default.
• W2736633767 creator A5048456616 @default.
• W2736633767 creator A5050744570 @default.
• W2736633767 creator A5065299486 @default.
• W2736633767 date "2017-07-21" @default.
• W2736633767 modified "2023-10-14" @default.
• W2736633767 title "In Vitro comparison of 213Bi- and 177Lu-radiation for peptide receptor radionuclide therapy" @default.
• W2736633767 cites W1558042969 @default.
• W2736633767 cites W1979219212 @default.
• W2736633767 cites W1984398166 @default.
• W2736633767 cites W1998403654 @default.
• W2736633767 cites W2000403342 @default.
• W2736633767 cites W2015635338 @default.
• W2736633767 cites W2018649196 @default.
• W2736633767 cites W2032747682 @default.
• W2736633767 cites W2037635280 @default.
• W2736633767 cites W2068030704 @default.
• W2736633767 cites W2075513808 @default.
• W2736633767 cites W2077814905 @default.
• W2736633767 cites W2091630347 @default.
• W2736633767 cites W2098590365 @default.
• W2736633767 cites W2112884695 @default.
• W2736633767 cites W2114600188 @default.
• W2736633767 cites W2121397606 @default.
• W2736633767 cites W2124325993 @default.
• W2736633767 cites W2127000806 @default.
• W2736633767 cites W2127810105 @default.
• W2736633767 cites W2131654458 @default.
• W2736633767 cites W2132937407 @default.
• W2736633767 cites W2147566707 @default.
• W2736633767 cites W2158164634 @default.
• W2736633767 cites W2161837289 @default.
• W2736633767 cites W2226900762 @default.
• W2736633767 cites W2253304324 @default.
• W2736633767 cites W2266239643 @default.
• W2736633767 cites W2351070318 @default.
• W2736633767 cites W2553758159 @default.
• W2736633767 doi "https://doi.org/10.1371/journal.pone.0181473" @default.
• W2736633767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5521788" @default.
• W2736633767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28732021" @default.
• W2736633767 hasPublicationYear "2017" @default.
• W2736633767 type Work @default.
• W2736633767 sameAs 2736633767 @default.
• W2736633767 citedByCount "31" @default.
• W2736633767 countsByYear W27366337672018 @default.
• W2736633767 countsByYear W27366337672019 @default.
• W2736633767 countsByYear W27366337672020 @default.
• W2736633767 countsByYear W27366337672021 @default.
• W2736633767 countsByYear W27366337672022 @default.
• W2736633767 countsByYear W27366337672023 @default.
• W2736633767 crossrefType "journal-article" @default.
• W2736633767 hasAuthorship W2736633767A5000332171 @default.
• W2736633767 hasAuthorship W2736633767A5007539874 @default.
• W2736633767 hasAuthorship W2736633767A5011219611 @default.
• W2736633767 hasAuthorship W2736633767A5040369608 @default.
• W2736633767 hasAuthorship W2736633767A5048456616 @default.
• W2736633767 hasAuthorship W2736633767A5050744570 @default.
• W2736633767 hasAuthorship W2736633767A5065299486 @default.
• W2736633767 hasBestOaLocation W27366337671 @default.
• W2736633767 hasConcept C111337013 @default.
• W2736633767 hasConcept C11928243 @default.
• W2736633767 hasConcept C121332964 @default.
• W2736633767 hasConcept C139770010 @default.
• W2736633767 hasConcept C1491633281 @default.
• W2736633767 hasConcept C151337348 @default.
• W2736633767 hasConcept C177322064 @default.
• W2736633767 hasConcept C185544564 @default.
• W2736633767 hasConcept C185592680 @default.
• W2736633767 hasConcept C2989005 @default.
• W2736633767 hasConcept C2993559085 @default.
• W2736633767 hasConcept C55493867 @default.
• W2736633767 hasConcept C71924100 @default.
• W2736633767 hasConcept C75088862 @default.
• W2736633767 hasConcept C86611320 @default.
• W2736633767 hasConceptScore W2736633767C111337013 @default.
• W2736633767 hasConceptScore W2736633767C11928243 @default.
• W2736633767 hasConceptScore W2736633767C121332964 @default.
• W2736633767 hasConceptScore W2736633767C139770010 @default.
• W2736633767 hasConceptScore W2736633767C1491633281 @default.
• W2736633767 hasConceptScore W2736633767C151337348 @default.
• W2736633767 hasConceptScore W2736633767C177322064 @default.
• W2736633767 hasConceptScore W2736633767C185544564 @default.
• W2736633767 hasConceptScore W2736633767C185592680 @default.
• W2736633767 hasConceptScore W2736633767C2989005 @default.
• W2736633767 hasConceptScore W2736633767C2993559085 @default.
• W2736633767 hasConceptScore W2736633767C55493867 @default.
• W2736633767 hasConceptScore W2736633767C71924100 @default.
• W2736633767 hasConceptScore W2736633767C75088862 @default.
• W2736633767 hasConceptScore W2736633767C86611320 @default.
• W2736633767 hasIssue "7" @default.
• W2736633767 hasLocation W27366337671 @default.
• W2736633767 hasLocation W27366337672 @default.
• W2736633767 hasLocation W27366337673 @default.

• next