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• W2736638081 endingPage "71284" @default.
• W2736638081 startingPage "71249" @default.
• W2736638081 abstract "During the last decades, the pleiotropic antitumor functions exerted by type I interferons (IFNs) have become universally acknowledged, especially their role in mediating interactions between the tumor and the immune system. Indeed, type I IFNs are now appreciated as a critical component of dendritic cell (DC) driven T cell responses to cancer. Here we focus on IFN-α and IFN-β, and their antitumor effects, impact on immune responses and their use as therapeutic agents. IFN-α/β share many properties, including activation of the JAK-STAT signaling pathway and induction of a variety of cellular phenotypes. For example, type I IFNs drive not only the high maturation status of DCs, but also have a direct impact in cytotoxic T lymphocytes, NK cell activation, induction of tumor cell death and inhibition of angiogenesis. A variety of stimuli, including some standard cancer treatments, promote the expression of endogenous IFN-α/β, which then participates as a fundamental component of immunogenic cell death. Systemic treatment with recombinant protein has been used for the treatment of melanoma. The induction of endogenous IFN-α/β has been tested, including stimulation through pattern recognition receptors. Gene therapies involving IFN-α/β have also been described. Thus, harnessing type I IFNs as an effective tool for cancer therapy continues to be studied." @default.
• W2736638081 created "2017-07-31" @default.
• W2736638081 creator A5015479693 @default.
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• W2736638081 creator A5060873077 @default.
• W2736638081 creator A5083466179 @default.
• W2736638081 creator A5085078487 @default.
• W2736638081 date "2017-07-25" @default.
• W2736638081 modified "2023-10-17" @default.
• W2736638081 title "Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy" @default.
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