FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736690764> ?p ?o ?g. }

• W2736690764 endingPage "1490" @default.
• W2736690764 startingPage "1482" @default.
• W2736690764 abstract "Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. We previously identified LHX3 as a new preferentially expressed gene in NSCLC. In the present study, we sought to determine its expression, the clinical relevance and the functional roles in NSCLC. LHX3 expression is sharply increased in carcinoma tissues compared to non-carcinoma tissues. Relational analysis reveals a significant association between LHX3 expression and clinical stage (n=172, p=0.032) or radiotherapy (n=167, p=0.022) of patients. LHX3 expression is much higher in the patients at advanced stages (stage III-IV) than in the patients at early stages (stage I-II, p=0.0304), and LHX3 expression is remarkably increased in the patients with radiotherapy treatment (p=0.0002). Survival analyses indicate that LHX3 is associated with unfavorable survival (n=180, p=0.002) and represents an independent prognostic factor [hazard ratio (HR)=1.834, p=0.004] of the NSCLC patients. Furthermore, LHX3 is associated with unfavorable overall survival (n=866, p=0.004) and represents an independent prognostic factor (HR=2.36, p=0.000) in lung adenocarcinoma (ADC) patients, but is not associated with overall survival of squamous cell carcinoma (SCC) patients (n=524, p=0.27). Further analyses found that LHX3 is an early-stage (n=94, p=0.003) and radiosensitivity (n=45, p=0.002) prognostic factor in ADC patients. The patients without radiotherapy have a significantly prolonged survival compared to those with radiotherapy (p=0.0069). Further functional studies show that forced expression of LHX3 in lung cancer cells obviously promotes cell proliferation and invasion, whereas inhibits cell apoptosis. In summary, LHX3 is an early-stage and radiosensitivity prognostic biomarker, and a novel potential oncogene in ADC." @default.
• W2736690764 created "2017-07-31" @default.
• W2736690764 creator A5011567211 @default.
• W2736690764 creator A5022515173 @default.
• W2736690764 creator A5023952711 @default.
• W2736690764 creator A5061873068 @default.
• W2736690764 creator A5066182565 @default.
• W2736690764 creator A5083960636 @default.
• W2736690764 creator A5090372209 @default.
• W2736690764 creator A5090937408 @default.
• W2736690764 date "2017-03-01" @default.
• W2736690764 modified "2023-09-27" @default.
• W2736690764 title "LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma" @default.
• W2736690764 cites W1273298230 @default.
• W2736690764 cites W1501475362 @default.
• W2736690764 cites W1956090617 @default.
• W2736690764 cites W1963802469 @default.
• W2736690764 cites W1971043408 @default.
• W2736690764 cites W1979538859 @default.
• W2736690764 cites W1980640097 @default.
• W2736690764 cites W1982737320 @default.
• W2736690764 cites W1997505389 @default.
• W2736690764 cites W2009266803 @default.
• W2736690764 cites W2018216158 @default.
• W2736690764 cites W2018270751 @default.
• W2736690764 cites W2040935952 @default.
• W2736690764 cites W2045138941 @default.
• W2736690764 cites W2054841768 @default.
• W2736690764 cites W2059086372 @default.
• W2736690764 cites W2076218943 @default.
• W2736690764 cites W2080966254 @default.
• W2736690764 cites W2090029719 @default.
• W2736690764 cites W2091138462 @default.
• W2736690764 cites W2094145003 @default.
• W2736690764 cites W2110518419 @default.
• W2736690764 cites W2112149426 @default.
• W2736690764 cites W2113077232 @default.
• W2736690764 cites W2122656254 @default.
• W2736690764 cites W2126496132 @default.
• W2736690764 cites W2140847299 @default.
• W2736690764 cites W2147286234 @default.
• W2736690764 cites W2156050765 @default.
• W2736690764 cites W2158734599 @default.
• W2736690764 cites W2160112112 @default.
• W2736690764 cites W2165948908 @default.
• W2736690764 cites W2170149445 @default.
• W2736690764 cites W2479048049 @default.
• W2736690764 cites W4234236664 @default.
• W2736690764 doi "https://doi.org/10.3892/or.2017.5833" @default.
• W2736690764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5549242" @default.
• W2736690764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28731174" @default.
• W2736690764 hasPublicationYear "2017" @default.
• W2736690764 type Work @default.
• W2736690764 sameAs 2736690764 @default.
• W2736690764 citedByCount "4" @default.
• W2736690764 countsByYear W27366907642020 @default.
• W2736690764 countsByYear W27366907642021 @default.
• W2736690764 countsByYear W27366907642022 @default.
• W2736690764 countsByYear W27366907642023 @default.
• W2736690764 crossrefType "journal-article" @default.
• W2736690764 hasAuthorship W2736690764A5011567211 @default.
• W2736690764 hasAuthorship W2736690764A5022515173 @default.
• W2736690764 hasAuthorship W2736690764A5023952711 @default.
• W2736690764 hasAuthorship W2736690764A5061873068 @default.
• W2736690764 hasAuthorship W2736690764A5066182565 @default.
• W2736690764 hasAuthorship W2736690764A5083960636 @default.
• W2736690764 hasAuthorship W2736690764A5090372209 @default.
• W2736690764 hasAuthorship W2736690764A5090937408 @default.
• W2736690764 hasBestOaLocation W27366907641 @default.
• W2736690764 hasConcept C121608353 @default.
• W2736690764 hasConcept C126322002 @default.
• W2736690764 hasConcept C143998085 @default.
• W2736690764 hasConcept C146357865 @default.
• W2736690764 hasConcept C151730666 @default.
• W2736690764 hasConcept C206684579 @default.
• W2736690764 hasConcept C207103383 @default.
• W2736690764 hasConcept C2776256026 @default.
• W2736690764 hasConcept C2777546739 @default.
• W2736690764 hasConcept C2781018059 @default.
• W2736690764 hasConcept C2781182431 @default.
• W2736690764 hasConcept C29537977 @default.
• W2736690764 hasConcept C44249647 @default.
• W2736690764 hasConcept C50382708 @default.
• W2736690764 hasConcept C509974204 @default.
• W2736690764 hasConcept C63363279 @default.
• W2736690764 hasConcept C71924100 @default.
• W2736690764 hasConcept C86803240 @default.
• W2736690764 hasConceptScore W2736690764C121608353 @default.
• W2736690764 hasConceptScore W2736690764C126322002 @default.
• W2736690764 hasConceptScore W2736690764C143998085 @default.
• W2736690764 hasConceptScore W2736690764C146357865 @default.
• W2736690764 hasConceptScore W2736690764C151730666 @default.
• W2736690764 hasConceptScore W2736690764C206684579 @default.
• W2736690764 hasConceptScore W2736690764C207103383 @default.
• W2736690764 hasConceptScore W2736690764C2776256026 @default.
• W2736690764 hasConceptScore W2736690764C2777546739 @default.
• W2736690764 hasConceptScore W2736690764C2781018059 @default.
• W2736690764 hasConceptScore W2736690764C2781182431 @default.

• next