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- W2736698312 abstract "Four octapeptide analogs, Pro-Asn-Pro-Phe-Phe-Gly-Leu-Met-NH2 [65535-22-0], Pro-Gln-Pro-Phe-Phe-Gly-Leu-Met-NH2 [65535-23-1], Pro-Asn-Tyr-Phe-Phe-Gly-Leu-Met-NH2 [65535-24-2], and Pro-Gln-Tyr-Phe-Phe-Gly-Leu-Met-NH2 [65535-25-3] corresponding to the C-terminal sequence of physalaemin [2507-24-6] were synthesized in the solid phase using Boc-amino acid active esters in the presence of 1-hydroxybenzotriazole. The acidic amino acid tyrosine at position 8 and the basic lysine at position 6 could be replaced by neutral amino acids without much loss of activity (contraction of guinea pig ileum). But replacement of the basic amino acid lysine at position 6 by an acidic amino acid, tyrosine, decreased the activity." @default.
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- W2736698312 date "1977-01-01" @default.
- W2736698312 modified "2023-09-27" @default.
- W2736698312 title "Peptides related to physalaemin-III" @default.
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