FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736702546> ?p ?o ?g. }

• W2736702546 abstract "Elevated free fatty acids (FFAs) in obesity are known risk factors associated with chronic inflammatory conditions including cardiovascular inflammation and thus cardiovascular disease (CVD), the leading cause of death in the US. Anthocyanins from berries have the potential to provide protection against inflammation in various tissues; however they are poorly absorbed and undergo major transformations by the microbiome. The work presented in this dissertation involves the development and utilization of an in vitro model to characterize the products of colonic fermentation and absorption of blueberry and black raspberry pomace phenolics, and evaluate the potential efficacy of these products compared to anthocyanin-rich extracts as anti-inflammatory compounds in fatty acid-induced inflammation. A previous study identified myristic and palmitic acids as the most inflammatory, and linoleic acid as least inflammatory. In the first study, a model of colonic fermentation and transport through Caco-2 cells was used to evaluate the changes in phenolic profile of blueberry and black raspberry pomaces. Phenolic acids deriving from anthocyanin degradation were identified as the major products of berry pomace digestion and absorption. The second study involved the use of palmitic acid-stimulated HCAE and HCASM cells to evaluate the anti-inflammatory properties of anthocyanin-rich extracts and phenolic acids produced by microbiota fermentation and transport across Caco-2 monolayers using the prevention and intervention approaches. Protein and gene expression of inflammation markers demonstrate that phenolic acids derived from fermentation and absorption of both blueberry and black raspberry pomaces were equally or more effective than anthocyanin-rich extracts in modulating the inflammatory response through a proposed effect on NF-κB transcription, especially when used in the prevention approach. This suggests that phenolic acids may be responsible for some of the beneficial effects of blueberries and black raspberries. We have also demonstrated that berry pomaces, could be utilized in foods, providing anthocyanins and phenolic acids that may prevent inflammation in cardiovascular cells." @default.
• W2736702546 created "2017-07-31" @default.
• W2736702546 creator A5002528080 @default.
• W2736702546 date "2022-06-10" @default.
• W2736702546 modified "2023-10-15" @default.
• W2736702546 title "Potential influence of blueberry and black raspberry pomace phenolics on inflammatory cytokines in coronary cells" @default.
• W2736702546 cites W1487834485 @default.
• W2736702546 cites W1492757267 @default.
• W2736702546 cites W1536161802 @default.
• W2736702546 cites W1536589127 @default.
• W2736702546 cites W1541570869 @default.
• W2736702546 cites W1574019439 @default.
• W2736702546 cites W1574459634 @default.
• W2736702546 cites W1868361743 @default.
• W2736702546 cites W1918965474 @default.
• W2736702546 cites W1926222251 @default.
• W2736702546 cites W1946242058 @default.
• W2736702546 cites W1964607854 @default.
• W2736702546 cites W1966521498 @default.
• W2736702546 cites W1966958501 @default.
• W2736702546 cites W1969614833 @default.
• W2736702546 cites W1970516435 @default.
• W2736702546 cites W1971154691 @default.
• W2736702546 cites W1974042803 @default.
• W2736702546 cites W1978069233 @default.
• W2736702546 cites W1978325636 @default.
• W2736702546 cites W1979196526 @default.
• W2736702546 cites W1980658595 @default.
• W2736702546 cites W1981145469 @default.
• W2736702546 cites W1981237781 @default.
• W2736702546 cites W1981471144 @default.
• W2736702546 cites W1981851376 @default.
• W2736702546 cites W1983625930 @default.
• W2736702546 cites W1986072494 @default.
• W2736702546 cites W1988530842 @default.
• W2736702546 cites W1988872568 @default.
• W2736702546 cites W1989708883 @default.
• W2736702546 cites W1990164787 @default.
• W2736702546 cites W1992658935 @default.
• W2736702546 cites W1992822368 @default.
• W2736702546 cites W1994109014 @default.
• W2736702546 cites W1994295724 @default.
• W2736702546 cites W1998194170 @default.
• W2736702546 cites W1998953697 @default.
• W2736702546 cites W2001062722 @default.
• W2736702546 cites W2002785084 @default.
• W2736702546 cites W2008266059 @default.
• W2736702546 cites W2010737064 @default.
• W2736702546 cites W2012652165 @default.
• W2736702546 cites W2014844547 @default.
• W2736702546 cites W2016299197 @default.
• W2736702546 cites W2017645793 @default.
• W2736702546 cites W2018861313 @default.
• W2736702546 cites W2019964351 @default.
• W2736702546 cites W2020555937 @default.
• W2736702546 cites W2021171647 @default.
• W2736702546 cites W2021684775 @default.
• W2736702546 cites W2023545430 @default.
• W2736702546 cites W2023647145 @default.
• W2736702546 cites W2026768120 @default.
• W2736702546 cites W2027367990 @default.
• W2736702546 cites W2027600763 @default.
• W2736702546 cites W2032837661 @default.
• W2736702546 cites W2033627334 @default.
• W2736702546 cites W2034725283 @default.
• W2736702546 cites W2037681243 @default.
• W2736702546 cites W2038242956 @default.
• W2736702546 cites W2038845325 @default.
• W2736702546 cites W2038961236 @default.
• W2736702546 cites W2039693707 @default.
• W2736702546 cites W2049365848 @default.
• W2736702546 cites W2049395875 @default.
• W2736702546 cites W2049583265 @default.
• W2736702546 cites W2056445309 @default.
• W2736702546 cites W2056717322 @default.
• W2736702546 cites W2058610272 @default.
• W2736702546 cites W2059123324 @default.
• W2736702546 cites W2064682657 @default.
• W2736702546 cites W2069212536 @default.
• W2736702546 cites W2070261059 @default.
• W2736702546 cites W2072380789 @default.
• W2736702546 cites W2074797215 @default.
• W2736702546 cites W2080457679 @default.
• W2736702546 cites W2085375471 @default.
• W2736702546 cites W2086057525 @default.
• W2736702546 cites W2088134976 @default.
• W2736702546 cites W2091124904 @default.
• W2736702546 cites W2092815169 @default.
• W2736702546 cites W2094050302 @default.
• W2736702546 cites W2094941678 @default.
• W2736702546 cites W2095089279 @default.
• W2736702546 cites W2098859779 @default.
• W2736702546 cites W2100419955 @default.
• W2736702546 cites W2105130082 @default.
• W2736702546 cites W2106124159 @default.
• W2736702546 cites W2111800800 @default.
• W2736702546 cites W2112452373 @default.
• W2736702546 cites W2125716538 @default.
• W2736702546 cites W2130585857 @default.
• W2736702546 cites W2131536959 @default.

• next