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- W2736703859 abstract "objective: To present the frequency of single nucleotide polymorphisms of a few immune response genes in a population sample from Sao Paulo City (SP), Brazil. Methods: Data on allele frequencies of known polymorphisms of innate and acquired immunity genes were presented, the majority with proven impact on gene function. Data were gathered from a sample of healthy individuals, non-HLA identical siblings of bone marrow transplant recipients from the Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, obtained between 1998 and 2005. The number of samples varied for each single nucleotide polymorphism analyzed by polymerase chain reaction followed by restriction enzyme cleavage. results: Allele and genotype distribution of 41 different gene polymorphisms, mostly cytokines, but also including other immune response genes, were presented. Conclusion: We believe that the data presented here can be of great value for case-control studies, to define which polymorphisms are present in biologically relevant frequencies and to assess targets for therapeutic intervention in polygenic diseases with a component of immune and inflammatory responses." @default.
- W2736703859 created "2017-07-31" @default.
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- W2736703859 date "2011-01-01" @default.
- W2736703859 modified "2023-09-27" @default.
- W2736703859 title "Frequência de polimorfismo de nucleotídeo único de alguns genes da resposta imune em amostra populacional da cidade de São Paulo, Brasil Frequency of single nucleotide polymorphisms of some immune response genes in a population sample from São Paulo, Brazil" @default.
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