FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736740875> ?p ?o ?g. }

• W2736740875 endingPage "e00364" @default.
• W2736740875 startingPage "e00364" @default.
• W2736740875 abstract "Interpreting the intricate bacterial transcriptomics implies understanding the dynamic relationship established between de novo transcription and the degradation of transcripts. Here, we performed a comparative overview of gene expression levels and mRNA decay rates for different-biovar (trachoma and lymphogranuloma venereum) strains of the obligate intracellular bacterium Chlamydia trachomatis. By using RNA-sequencing to measure gene expression levels at mid developmental stage and mRNA decay rates upon rifampicin-based transcription blockage, we observed that: i) 60–70% of the top-50 expressed genes encode proteins with unknown function and proteins involved in “Translation, ribosomal structure and biogenesis” for all strains; ii) the expression ranking by genes' functional categories was in general concordant among different-biovar strains; iii) the median of the half-life time (t1/2) values of transcripts were 15–17 min, indicating that the degree of transcripts’ stability seems to correlate with the bacterial intracellular life-style, as these values are considerably higher than the ones observed in other studies for facultative intracellular and free-living bacteria; iv) transcript decay rates were highly heterogeneous within each C. trachomatis strain and did not correlate with steady-state expression levels; v) only at very few instances (essentially at gene functional category level) was possible to unveil dissimilarities potentially underlying phenotypic differences between biovars. In summary, the unveiled transcriptomic scenario, marked by a general lack of correlation between transcript production and degradation and a huge inter-transcript heterogeneity in decay rates, likely reflects the challenges underlying the unique biphasic developmental cycle of C. trachomatis and its intricate interactions with the human host, which probably exacerbate the complexity of the bacterial transcription regulation." @default.
• W2736740875 created "2017-07-31" @default.
• W2736740875 creator A5027185958 @default.
• W2736740875 creator A5037909632 @default.
• W2736740875 creator A5052042621 @default.
• W2736740875 creator A5083995572 @default.
• W2736740875 date "2017-07-01" @default.
• W2736740875 modified "2023-10-16" @default.
• W2736740875 title "Global survey of mRNA levels and decay rates of Chlamydia trachomatis trachoma and lymphogranuloma venereum biovars" @default.
• W2736740875 cites W1497229653 @default.
• W2736740875 cites W1900158587 @default.
• W2736740875 cites W1909615236 @default.
• W2736740875 cites W1913071848 @default.
• W2736740875 cites W1969939375 @default.
• W2736740875 cites W1985186068 @default.
• W2736740875 cites W1986802990 @default.
• W2736740875 cites W1992724777 @default.
• W2736740875 cites W1995896010 @default.
• W2736740875 cites W2000964393 @default.
• W2736740875 cites W2008632716 @default.
• W2736740875 cites W2017111499 @default.
• W2736740875 cites W2019568888 @default.
• W2736740875 cites W2020783091 @default.
• W2736740875 cites W2030051155 @default.
• W2736740875 cites W2039708403 @default.
• W2736740875 cites W2043048525 @default.
• W2736740875 cites W2048454307 @default.
• W2736740875 cites W2054578516 @default.
• W2736740875 cites W2057693588 @default.
• W2736740875 cites W2060842569 @default.
• W2736740875 cites W2062896692 @default.
• W2736740875 cites W2063349139 @default.
• W2736740875 cites W2067872411 @default.
• W2736740875 cites W2068242488 @default.
• W2736740875 cites W2070063001 @default.
• W2736740875 cites W2076695023 @default.
• W2736740875 cites W2082469630 @default.
• W2736740875 cites W2085967390 @default.
• W2736740875 cites W2095433689 @default.
• W2736740875 cites W2098508116 @default.
• W2736740875 cites W2098878361 @default.
• W2736740875 cites W2098889266 @default.
• W2736740875 cites W2103222931 @default.
• W2736740875 cites W2105057548 @default.
• W2736740875 cites W2112456256 @default.
• W2736740875 cites W2115780677 @default.
• W2736740875 cites W2118453530 @default.
• W2736740875 cites W2120419610 @default.
• W2736740875 cites W2123634952 @default.
• W2736740875 cites W2124503920 @default.
• W2736740875 cites W2133117141 @default.
• W2736740875 cites W2133286749 @default.
• W2736740875 cites W2134440848 @default.
• W2736740875 cites W2134559590 @default.
• W2736740875 cites W2138472384 @default.
• W2736740875 cites W2139956963 @default.
• W2736740875 cites W2142926390 @default.
• W2736740875 cites W2144297593 @default.
• W2736740875 cites W2147256329 @default.
• W2736740875 cites W2148063376 @default.
• W2736740875 cites W2153055827 @default.
• W2736740875 cites W2158752325 @default.
• W2736740875 cites W2161666385 @default.
• W2736740875 cites W2162911097 @default.
• W2736740875 cites W2166866388 @default.
• W2736740875 cites W2396849069 @default.
• W2736740875 cites W2615056822 @default.
• W2736740875 cites W4211224178 @default.
• W2736740875 cites W2076660111 @default.
• W2736740875 doi "https://doi.org/10.1016/j.heliyon.2017.e00364" @default.
• W2736740875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5541142" @default.
• W2736740875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28795162" @default.
• W2736740875 hasPublicationYear "2017" @default.
• W2736740875 type Work @default.
• W2736740875 sameAs 2736740875 @default.
• W2736740875 citedByCount "10" @default.
• W2736740875 countsByYear W27367408752018 @default.
• W2736740875 countsByYear W27367408752019 @default.
• W2736740875 countsByYear W27367408752020 @default.
• W2736740875 countsByYear W27367408752021 @default.
• W2736740875 crossrefType "journal-article" @default.
• W2736740875 hasAuthorship W2736740875A5027185958 @default.
• W2736740875 hasAuthorship W2736740875A5037909632 @default.
• W2736740875 hasAuthorship W2736740875A5052042621 @default.
• W2736740875 hasAuthorship W2736740875A5083995572 @default.
• W2736740875 hasBestOaLocation W27367408751 @default.
• W2736740875 hasConcept C104317684 @default.
• W2736740875 hasConcept C138885662 @default.
• W2736740875 hasConcept C150194340 @default.
• W2736740875 hasConcept C159047783 @default.
• W2736740875 hasConcept C162317418 @default.
• W2736740875 hasConcept C179926584 @default.
• W2736740875 hasConcept C18903297 @default.
• W2736740875 hasConcept C24990904 @default.
• W2736740875 hasConcept C2777391075 @default.
• W2736740875 hasConcept C2778967756 @default.
• W2736740875 hasConcept C33922130 @default.
• W2736740875 hasConcept C41895202 @default.

• next