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• W2736761946 abstract "The pancreatic cancer is the fourth leading cause of cancer-related death and characterized by one of the lowest five-year survival rate. The current therapeutic options are demonstrating minimal effectiveness, therefore studies on new potential anticancer compounds, with non-significant side effects are highly desirable. Recently, it was demonstrated that vanadium compounds, in particular organic derivatives, exhibit anticancer properties against different type of tumor as well as favorable biodistribution from a pancreatic cancer treatment perspective. In this research, we showed selective cytotoxic effect of vanadium complexes, containing phenanthroline and quinoline as an organic ligands, against human pancreatic ductal adenocarcinoma cell line (PANC-1), compared to non-tumor human immortalized pancreas duct epithelial cells (hTERT-HPNE). Results exhibited that vanadium complexes inhibited autophagy process in selective cytotoxic concentration as well as caused the cell cycle arrest in G2/M phase associated with mitotic catastrophe and increased level of reactive oxygen species (ROS). Moreover, in higher concentration, vanadium derivatives induced a mix type of cell death in PANC-1 cells, including apoptotic and necroptotic process. Our investigation emphasizes the anticancer potential of vanadium complexes by indicating their selective cytotoxic activity, through different process posed by alternative type of cell deaths to apoptosis-resistant cancer cells. Further studies supporting the therapeutic potential of vanadium in pancreatic cancer treatment is highly recommended." @default.
• W2736761946 created "2017-07-31" @default.
• W2736761946 creator A5010056307 @default.
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• W2736761946 date "2017-07-22" @default.
• W2736761946 modified "2023-10-12" @default.
• W2736761946 title "Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process" @default.
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• W2736761946 cites W1539866419 @default.
• W2736761946 cites W1597331033 @default.
• W2736761946 cites W1757407923 @default.
• W2736761946 cites W1784425676 @default.
• W2736761946 cites W1920972430 @default.
• W2736761946 cites W1931508686 @default.
• W2736761946 cites W1959449289 @default.
• W2736761946 cites W1963521777 @default.
• W2736761946 cites W1964483580 @default.
• W2736761946 cites W1968812902 @default.
• W2736761946 cites W1970401962 @default.
• W2736761946 cites W1972723727 @default.
• W2736761946 cites W1974825648 @default.
• W2736761946 cites W1975667190 @default.
• W2736761946 cites W1981950106 @default.
• W2736761946 cites W1984510020 @default.
• W2736761946 cites W1989529289 @default.
• W2736761946 cites W1991590577 @default.
• W2736761946 cites W1992762994 @default.
• W2736761946 cites W1993416052 @default.
• W2736761946 cites W1993506009 @default.
• W2736761946 cites W1996416351 @default.
• W2736761946 cites W1997367417 @default.
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• W2736761946 cites W2009557486 @default.
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• W2736761946 cites W2016599680 @default.
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• W2736761946 cites W2020987391 @default.
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• W2736761946 cites W2026484986 @default.
• W2736761946 cites W2028666395 @default.
• W2736761946 cites W2030864103 @default.
• W2736761946 cites W2033324174 @default.
• W2736761946 cites W2040149266 @default.
• W2736761946 cites W2048030072 @default.
• W2736761946 cites W2050224146 @default.
• W2736761946 cites W2058170782 @default.
• W2736761946 cites W2059273158 @default.
• W2736761946 cites W2059738518 @default.
• W2736761946 cites W2060663852 @default.
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• W2736761946 cites W2158662692 @default.
• W2736761946 cites W2161830466 @default.
• W2736761946 cites W2164660906 @default.
• W2736761946 cites W2164972309 @default.
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• W2736761946 doi "https://doi.org/10.18632/oncotarget.19454" @default.
• W2736761946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5601142" @default.
• W2736761946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28947974" @default.
• W2736761946 hasPublicationYear "2017" @default.
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